Cell Biology
New study untangles how proteins ensure efficient DNA repair
Scientists have untangled the function of proteins that block normal DNA repair processes and may permit unwanted cancer cell growth. New research published in Molecular Cell on June 7 details how the XRCC1 molecular scaffold protein works in tandem with the poly(ADP-ribose) polymerase DNA break-detection protein to ensure that genetic errors are efficiently corrected. Read More
Waters debuts mass spectrometer with MRT technology
Waters has introduced its next-generation Select Series multireflecting time-of-flight (MRT) mass spectrometer. The new system is designed to provide high-quality resolution at fast speeds to improve the clarity of molecular structures and their location in tissues for applications in spatial omics. Read More
A new way to account for evolution in engineered biological systems
A defining characteristic of biology is that life evolves. Traditional biological engineering views an engineered product as a final destination in the design process. However, the authors of a perspective piece published in Nature Communications on June 7 believe that a new perspective is needed for engineering of biological systems -- one that takes into consideration how a biosystem will continue to evolve over time. Read More
Single-cell study discovers how antibody regulators develop in tissue
The development process of immune cells important for establishing long-term immunity has been revealed through detailed single-cell techniques. A new study, published in the journal Science Immunology on May 28, examined extracted tonsils and lymph nodes to establish how human T follicular cells specialize in the body. Read More
Researchers determine new classification system for DNA architecture across life
A novel classification system for cell nuclei has been proposed in a new study investigating genome folding across the entire tree of life. In the paper, published in Science on May 27, an international team of researchers also detailed a method for transmuting one type of cell nucleus into another. Read More
New research uncovers how SARS-CoV-2 hijacks RNA host proteins
A new study has uncovered the interactions that SARS-CoV-2 RNA establishes with the host cell proteins, many of which are fundamental for infection. The results, published in Molecular Cell on May 24, pave the way for the development of new therapeutic strategies for COVID-19 with broad-range antiviral potential. Read More
AI tracks cell movements in stem cell colonies
Scientists are still trying to understand how stem cell clusters assemble to form complex organs. To help demystify this phenomenon, researchers developed an ensemble of cell-tracking algorithms to track the movements in colonies of human induced pluripotent stem cells. The research demonstrates the potential of artificial intelligence (AI) in developmental biology. Read More
Potential of gene editing for clinical use highlighted at ASGCT 2021
From base editing to in vivo CRISPR therapeutics and CRISPR-modified bacteriophages, scientists discussed innovations in preclinical research that have allowed them to advance these unique products to the clinic during a scientific symposium at the 2021 American Society of Gene & Cell Therapy (ASGCT) virtual meeting. Read More
Leveraging optofluidics to make therapeutic antibody discovery easier
The need for speed and accuracy in the development of therapeutic antibodies has prompted Berkeley Lights to upgrade its optofluidic tools to help customers improve the quality of their therapeutic antibody products. John Proctor, PhD, senior vice president of antibody therapeutics at Berkeley Lights, spoke with ScienceBoard.net about some technological advancements the company has recently launched. Read More
Tiny mechanical forces can have a massive effect on T-cell activation
A new study reveals how tiny forces between T cells and their targets can help to jumpstart protective immune responses. Research published in Nature Communications on May 4 uses cutting edge microscopy techniques to track the association and dissociation between T cells and antigens. Read More
Conferences
Interphex 2021
October 19-21
New York City, New York United States
Building Biology in 3D Hybrid Symposium
October 26-27
La Jolla, California United States
Northeast Regional Laboratory Staff and Core Directors (NERLSCD) 2021
November 3-5
Portsmouth, New Hampshire United States
CPhI Worldwide 2021
November 9-11
Milan, Lombardia Italy
Society for Immunotherapy of Cancer (SITC) Annual Meeting
November 10-14
Washington, DC, District of Columbia United States
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