Cell Biology
Algorithm expands what scientists can uncover from individual cells
A new software tool can help researchers further utilize single-cell RNA sequencing data to learn more about individual cells by incorporating biologically relevant data into the analysis. The machine-learning algorithm, detailed in Genome Research on June 30, can be used to predict which transcription factors are most active in individual cells. Read More
Oncolytic viruses move closer to becoming effective cancer therapies
Scientists are identifying key factors that aid in the effectiveness of oncolytic viruses during the treatment of cancers, which could lead to better immunotherapies and inform clinicians which patients might benefit from the treatment. Findings from a June 22 Nature Communications article point to the clinical relevance and underlying mechanisms of a novel anticancer treatment. Read More
Twist acquires iGenomX for $35M
Twist Bioscience has acquired next-generation sequencing library preparation developer iGenomX for $35 million. The deal gives Twist a leg up in the shift from genotyping with static microarray platforms to using sequencing workflows. Read More
What makes immunotherapies successful in one tumor but not in others?
Researchers have developed a new framework to uncover pathophysiological and molecular features that determine the effectiveness of immunotherapies. The research, published in Nature Communications on June 29, provides an opportunity for improving patient care and gaining a deeper understanding of cancer immunotherapy mechanisms. Read More
Akoya teams up with Nikon, CrestOptics, Andor
Akoya Biosciences has formed partnerships with microscope providers Nikon, CrestOptics, and Andor to facilitate development of spatial biology applications via its Imaging Innovators Network. Read More
CAR-NK cells hold promise for solid tumors
A new cancer immunotherapy that leverages the ability of natural killer (NK) cells to discriminate between cancer and normal cells has shown promise in solid tumors. The technology incorporates the cancer-targeting ability of chimeric antigen receptors (CARs), according to data published in iScience on June 25. Read More
New in vitro models offer effective way to study respiratory viruses
A new accessible and scalable protocol for manufacturing in vitro lung cell models could have applications in the development of new therapies for respiratory viral infections and drug toxicology studies on human lungs. Details about the protocol were published in Stem Cells on June 21. Read More
How one mammalian DNA polymerase challenges the central dogma of biology
New research demonstrates how an unusual mammalian DNA polymerase can facilitate the conversion of RNA into DNA -- the opposite of normal polymerase function. The data, published in Science Advances on June 11, could challenge the central dogma of molecular biology that states that DNA makes RNA, which in turn makes proteins. Read More
How spatial biology can impact clinical translational research
Building on the success of single-cell technologies, 10X Genomics' Michael Schnall-Levin, PhD, discusses with ScienceBoard.net how the company entered the spatial biology field and how it continues to support the advancement of various clinical translational research efforts. Read More
New study untangles how proteins ensure efficient DNA repair
Scientists have untangled the function of proteins that block normal DNA repair processes and may permit unwanted cancer cell growth. New research published in Molecular Cell on June 7 details how the XRCC1 molecular scaffold protein works in tandem with the poly(ADP-ribose) polymerase DNA break-detection protein to ensure that genetic errors are efficiently corrected. Read More
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