Tau PET reveals patterns of early Alzheimer's disease
Positron emission tomography (PET) scans in patients with early Alzheimer's disease reveal patterns of tau deposits that could help researchers improve the selection of at-risk patients for new drug trials, according to a study published April 18 in JAMA Neurology. Read More
Combined imaging approach gives detailed picture of blood vessels
Mapping out the intricate network of blood vessels in tissues can help researchers to better understand the changes in diseases like dementia or cancer. However, techniques to image the vasculature are individually limited and difficult to combine. Now, a new easy-to-use system, described in a paper published February 10 in the journal Nature Methods, can combine multiple imaging techniques to provide more detailed information at a range of scales. Read More
Atlas finds hundreds of genes that control the brain's shape
The shapes of our brains are heavily influenced by our genes, although the precise nature of this complex relationship is difficult to pin down. Now, a study published on February 3 in Science has used a genetics-based atlas of the cerebral cortex to identify hundreds of new gene variants that are linked to growth of specific regions. Read More
CHOP uses AI to find genetic causes of mental health disorders
Minority populations have been historically underrepresented in existing studies addressing how genetic variations may contribute to a variety of disorders. A new study from researchers at the Children's Hospital of Philadelphia (CHOP) addresses this lack of representation, showing that a deep learning model has promising accuracy when helping to diagnose a variety of common mental health disorders in African American patients. Read More
Creating an opening for treatments into the brains of mice
The cellular barrier that protects the brain also has the unfortunate effect of preventing medical treatments from reaching areas of the brain where they are needed. This presents a major obstacle in developing new drugs to treat brain diseases. Now, in a study published in Nature Protocols, researchers describe an approach in mice to precisely open a gate in the barrier and deliver therapeutic agents. Read More
Kevin DeGeeter in 5 questions, part of Biotech Finance Month 2022
Scientific innovation is happening at an ultrasonic rate these days, but what does this mean for cancer patients and their treatment options? This was the topic of "Outsmarting Cancer: Next Generation Therapies," a session at Biotech Showcase 2022. Kevin DeGeeter, managing director and senior analyst, biotechnology and diagnostics, at Oppenheimer, moderated the robust panel discussion and shared his insights with ScienceBoard as part of Biotech Finance Month 2022. Read More
Stem cell model reveals gene expression during development of hypothalamus
Researchers created an in vitro stem cell model of the hypothalamus to study its development over different stages. In doing so, they identified several genes involved with bodily functions associated with the hypothalamus, including disorders related to sleep and reproduction, according to research published November 19 in Nature Communications. Read More
Scientists create atlas of mouse brain regions down to single cells
An atlas of the mouse cerebrum and primary motor cortex down to the level of single cells was published in a pair of papers on October 6 in Nature. The research reveals the mammalian brain's organization at an unprecedented level of detail and sheds new light on gene regulatory factors, promising to inform future work on developing targeted therapies for human diseases. Read More
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