Immunology
FDA researchers describe lessons learned from COVID-19 immunology
Key immunological factors underlying the clinical stages of COVID-19 that could be targeted by therapeutic drugs is outlined in a review by U.S. Food and Drug Administration (FDA) researchers and published in Frontiers in Immunology on May 29.  Discuss
Need for efficiency, COVID-19 vaccine spurs biomanufacturing in 2020
With the urgent need for COVID-19 therapies and vaccines, funding agencies have prioritized biomanufacturing; companies in turn are preparing to ramp up a variety of biologics. The strong demand for bioprocessed medicines in 2020 will continue to drive growth of the industry.  Discuss
Will SARS-CoV-2 become an endemic seasonal coronavirus?
U.K. virologists have reviewed over 40 studies on SARS-CoV-2 immunity and discussed how this current knowledge about immune responses can inform virus control strategies. They shared their analysis in an article published in the Journal of General Virology on May 20.  Discuss
Big data analysis of images may aid vaccine development
A new pipeline that combines high-dimensional microscopy with big data analysis to gain molecular insights in T-cell biology and vaccine development was introduced in a paper published in Cell Systems on May 20.  Discuss
SARS-CoV mAb shown to block SARS-CoV-2
Antibodies from recovered SARS-CoV patients appear to block SARS-CoV-2 infectivity and could help in the development of antiviral treatments or vaccines, according to a new study. The findings were published in Nature on May 18.  Discuss
Are interferons a viable therapeutic intervention for COVID-19?
Significantly improved viral clearance and reductions in inflammatory cytokines are observed in COVID-19 patients treated with interferons, according to an exploratory study published in Frontiers in Immunology on May 15.  Discuss
Researchers explore role of cytokine storm in severe COVID-19
An overreaction of the immune system to SARS-CoV-2 -- a phenomenon known as cytokine storm -- has emerged as a major contributor to patient mortality during the COVID-19 outbreak. In a recent series of papers, authors examined cytokine storm and offered perspectives on preventing it from occurring.  Discuss
NIH leadership discusses COVID-19 vaccine collaborations
Public-private partnerships could help meet the unprecedented need to manufacture and distribute safe and effective COVID-19 vaccines around the globe, according to leaders from the U.S. National Institutes of Health (NIH) and the Fred Hutchinson Cancer Research Center. They discussed how in Science on May 11.  Discuss
Pangolin genome offers insight into SARS-CoV-2's jump to humans
Research into the source of SARS-CoV-2 in China has focused on pangolins, anteater-like mammals that may have harbored the virus before it jumped to humans. New findings published May 8 in Frontiers in Immunology indicate pangolins may lack two virus-sensing genes, making them more susceptible to being carriers of coronaviruses.  Discuss
Genomic tools help researchers understand how SARS-CoV-2 is evolving
A new study has identified nearly 200 recurrent genetic mutations in the SARS-CoV-2 virus, according to research published as a preproof in Infection, Genetics and Evolution on May 5. The findings could offer clues to how the virus is adapting and evolving in humans and lead to optimal drug and vaccine targets.  Discuss
Conferences
2nd Annual Cell Therapy Bioprocessing Conference
June 25-26
Boston, Massachusetts United States
BioProcess International Europe
July 13-16
Amsterdam, Noord-Holland Netherlands
Bioprocess International West
August 10-13
Santa Clara, California United States
General Discussion
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