Cell & Developmental Biology

Protein receptors imaged by cryoelectron microscopy help scientists understand inflammation
Researchers at Oregon Health & Science University used cryoelectron microscopy (cryo-EM) to observe protein structure and function at a molecular level. This discovery, published in Cell on October 3 describes the structure of P2X receptor, a cellular membrane protein receptor, and provides insight into how the cation channel functions.  Discuss
Driven by nanotech and other micro technologies electron microscopy market continues to grow
According to a new report from Strategic Directions International (SDI), the total market for electron microscopy instrumentation was in excess of $2.5 billion in 2018 and is expected to reach nearly $3.4 billion by 2023.  Discuss
Forward-oriented gene therapy improves treatment for sickle cell disease
Researchers at the National Institutes of Health (NIH) have developed a new and improved viral vector that is up to 10 times more efficient at incorporating corrective genes into bone marrow stem cells than conventional treatments. The work was published in Nature Communications on October 2, and was supported by the National Heart Lung, and Blood Institute (NHLBI) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the NIH.  Discuss
Understanding bacterial motility using cryogenic electron microscopy
A new finding reported in Nature Structural & Molecular Biology on October 1 shows how bacterial transmit motion from an inner motor to an outer tail through a flexible joint in the flagellum. This hook helps researchers understand how bacteria move and allows them to improve therapies against bacterial infections.  Discuss
Science Board Member Spotlight: Mona Batish, PhD
The Science Advisory Board is pleased to bring you a new series that focuses on the most essential part of the scientific process: you!
Oncogene identified as a therapeutic target for liver cancer
The function of an enzyme that is highly expressed in many cancers has been revealed to regulate key pathways in cancer metabolic adaptation. Researchers at the Georgia Cancer Center and Medical College of Georgia at Augusta University published their findings in Hepatology.  Discuss
New drug target identified for common brain cancer
Research led by the Cleveland Clinic has identified a potential new therapy in the treatment of glioblastoma. An article published in Cancer Discovery on August 21, identifies FGF2 (fibroblast growth factor 2), as a novel drug target for glioblastoma, the most common primary malignant brain tumor.  Discuss
Super-resolution using standard optical microscopes now possible with the aid of upconversion nanoparticles
Researchers at the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP) in Australia have found an innovative way to utilize standard laboratory optical imaging equipment to bypass diffraction limitations and achieve super-resolution. Results published in Nature Communications on August 16 provide methodology and theoretical framework for end-users to achieve super-resolution in their own laboratories.  Discuss
Visualizing big data in the life sciences gets an upgrade with new software
A new software developed by researchers at the Max Delbrück Center for Molecular Medicine (MDC) uses algorithms to reconstruct and scale data acquired by light-sheet microscopy that renders a supercomputer unnecessary. Light microscopy techniques provide extremely detailed information but result in terabytes of data which is nearly impossible for scientists to process. MDC researchers are helping make sense of this data.  Discuss
Functionality of small protein determined - potential to develop new therapies for Parkinson’s disease
A small protein, alpha-synuclein, has been found to be associated with the prevention of Parkinson’s disease. Scientists at Oregon Health & Science University (OSHU) published results in the journal Scientific Reports on July 29, 2019 showing that alpha-synuclein has a role in repairing breaks in DNA.  Discuss
Conferences
Virology, Emerging Diseases & Vaccines
October 21-22
Amsterdam Netherlands
10th CNS Summit
October 31 - November 3
Boca Raton, Florida United States
11th Annual PEGS Europe
November 18-22
Lisbon Portugal
Antibody Engineering & Therapeutics
December 9-13
San Diego, California United States
Society for Laboratory Automation and Screening (SLAS) 2020
January 25-29, 2020
San Diego, California United States
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