Scientists discover new pathway to treat glioblastoma
July 25, 2022 -- Researchers have developed a biomimetic formulation using nanoparticles for lactate metabolism-based synergistic therapy to fight against the brain cancer glioblastoma multiforme. Read More
Spanish researchers unlock the mystery of multidrug resistance
July 25, 2022 -- A team from the Spanish National Cancer Research Centre has determined that mutations that inactivate the function of a particular gene, FBXW7, reduce the sensitivity to the vast majority of drugs and result in multidrug resistance, according to a study published July 21 in EMBO Molecular Medicine. Read More
Analysis of nanoparticles, cancer cells could aid development of nanoparticle-based drugs
July 22, 2022 -- Researchers have identified biomarkers that predict whether different types of cancer cells will take up specific nanoparticles, potentially helping to overcome some obstacles to the development of nanoparticle-based drugs. Read More
New DNA editing tool could enable more personalized cell therapies
July 21, 2022 -- University of Minnesota, Twin Cities researchers have developed a new tool to predict and customize the rate of a type of DNA editing called site-specific recombination, offering the potential for more personalized cell therapies. Read More
Immunotherapy-KRAS inhibitor combination shows promise for lung cancer treatment
July 21, 2022 -- Immunotherapy plus a KRAS inhibitor drug could be a promising new treatment for certain lung tumors, U.K. researchers found. Read More
Study shows potential of CRISPR-Cas9 tools for synthetic gene control, cellular engineering
July 18, 2022 -- Rice University researchers were able to use deactivated Cas9 (dCas9) proteins to target key segments of the human genome to synthetically trigger the transcription of human genes. Using dCas9 proteins, researchers have revealed important details about human promoters and enhancers. Read More
New stem cell mechanism in mice intestines has potential human application
July 13, 2022 -- Researchers have found a new biophysical mechanism that regulates stem cells in the intestines of mice, which could have implications for potential new treatments for human diseases. Read More
CRISPR reveals interconnected map of immune feedback loops, regulatory networks
July 12, 2022 -- The disruption of thousands of genes using CRISPR-Cas9 gene editing has revealed a map of how human immune cells function. The resulting map could reveal the collections of genes that need to function properly to prevent immune diseases. Read More
Study finds cancer cells gravitate toward mechanical ‘sweet spot’ environments
July 12, 2022 -- An international team of researchers, led by University of Minnesota Twin Cities engineers, has discovered that cancer cells invade the body based on the stiffness of their environment, providing a new understanding of how cancer spreads and the potential for improvements to future treatments. Read More
Researchers identify which mice not to use for sickle cell disease studies
July 11, 2022 -- Researchers in Memphis, TN, have learned why certain mice die when testing new gene-based therapies for sickle cell disease and encourage scientists to carefully consider the genetics of the mice they are using to study human diseases. Read More
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