Researchers develop 'wise counsel' for biological systems
July 11, 2022 -- Researchers at the Max Planck Institute for Terrestrial Microbiology created Machine Learning Guided Experimental Trials for Improvement of Systems, a modular software system for optimizing biological systems. Read More
Single-cell sequencing finds subset of CAR T cells that drive anticancer effects
July 8, 2022 -- A small subset of the CAR T cells prepared for therapy produce most of the anticancer activity, suggesting it may be possible to improve the treatment, according to a study published in the journal Cancer Discovery. Read More
Large DNA insertions in CRISPR-edited cells could increase cancer risk: study
July 7, 2022 -- CRISPR-Cas9 can cause large rearrangements of DNA through retrotransposition to theoretically trigger tumor development, according to a paper published in Nature Communications. Read More
Mini kidneys reveal secrets of tuberous sclerosis complex
July 7, 2022 -- Researchers from Ottawa, Ontario have discovered which cells cause tumors in patients with tuberous sclerosis complex by creating genetically engineered kidney organoids, or “mini kidneys” grown from human tissue. Read More
Plant-microbe biology study uncovers trigger for tumor growth in humans
July 6, 2022 -- Targeting the plasminogen-apple-nematode domain can block cell proliferation, pointing to the potential to treat certain cancers, according to a paper published in the journal Communications Biology. Read More
Scientists able to visualize mRNA molecules in brains of living mice
July 6, 2022 -- A team of researchers has developed a new imaging technique that gives scientists a real-time view into mRNA synthesis and gene expression in the brain of a mouse while it is still alive. Read More
Researchers find how EGFR sends signals into cells, could help cancer drug design
July 6, 2022 -- Chemists at the Massachusetts Institute of Technology have revealed how the epidermal growth factor receptor (EGFR) changes its shape when it binds to its target and how those changes trigger cells to grow and proliferate. Their insights into EGFR could help researchers design new cancer drugs that target this protein. Read More
Global consortium creates 'largest' zebrafish genetic atlas to support human disease research
July 5, 2022 -- An international consortium of 27 laboratories called DANIO-CODE has created an atlas of genetic data on zebrafish to support research into conditions including cancer, heart disease, and neurodegeneration. Read More
Single DNA strand cuts achieve safety and efficacy edge over CRISPR-Cas9 in fruit flies
July 5, 2022 -- CRISPR-Cas9 variants known as “nickases” that target a single DNA strand may increase the success rate of gene editing and reduce the risk of off-target mutations, according to a paper published in the journal Science Advances. Read More
Certain gene protects against dementia in mice
July 5, 2022 -- Researchers in Japan discovered that the gene p62 plays a neuroprotective role in mice models of dementia by eliminating and thus preventing the aggregation of oligomeric tau species in the brain according to an article published in the journal Aging Cell. Read More
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