Immunology Sponsored by Beckman Coulter
New populations of lung cells identified which could aid in the treatment of chronic respiratory diseases
New research confirms the existence of two new subpopulations interstitial macrophages (IM), which are crucial to the pulmonary immune system. Published in Nature Communications on August 3, researchers from the Immunophysiology Laboratory of the GIGA Institute at the University of Liege provide insights into the characterization of these IM.  Discuss
Vaccine in development against hypervirulent Klebsiella
Concerns arising over the development of hypervirulent strains of Klebsiella pneumoniae have led researchers to develop an entirely new vaccine to protect against the gram-negative bacteria. A team of researchers at Washington University School of Medicine in St. Louis and VaxNewMo (a startup based in St. Louis) designed the vaccine by genetically manipulating E. coli. The details of the prototype designed were published in the Proceedings of the National Academy of Sciences on August 27th.  Discuss
Success of immunotherapies increased in cancer patients through co-treatment with monoclonal antibodies
A new approach provides evidence that it is possible to break down the protective wall surrounding tumor cells, therefore making immunotherapies more effective in patients with a variety of cancers. This research, funded by Cancer Research UK, was published in the EBioMedicine on August 25th.  Discuss
Thermally stable TB vaccine may now be possible thanks to an innovative new process
Researchers at the University of Bath have developed a process that protects vaccines from heat damage by trapping them in silica cages. The results were published in Scientific Reports on August 8, 2019. Using a leading candidate in the development on new vaccines, Ag85b in conjunction with adjuvant Sbi-Ag85b, thermal stability of tested using a novel process called ensilication.  Discuss
New immunotherapy moves further into clinical testing with promising results
Success in international clinical trials leads to U.S. based research organizations beginning phase I/II clinical trials. If this form of immunotherapy is successful and deemed safe, then it could save the lives of liver cancer patients across the world.  Discuss
Structure-based vaccine design may help save the lives of infants and children
A new experimental vaccine, utilizing structure-based design, shows promise in a phase I clinical trial. The vaccine will protect against respiratory syncytial virus (RSV), a leading cause of infectious disease deaths in infants. Researchers at the University of Texas at Austin published findings on Aug 2, 2019 in Science stating that one dose elicited increases in RSV-neutralizing antibodies over several months.  Discuss
The European Commission pursues open science and why it’s important
Scientists believe that there is a reproducibility crisis in the scientific community where many scientists fail to reproduce experiments, according to a new report by Science | Business in July 2019. Open science is a high priority for the European Commission, with around 70% of all data generated by EU-funded programs being accessible to the public.  Discuss
CAR-T cell therapy research shows encouraging signs for mesothelioma patients
Every year, nearly 3,000 new cases of mesothelioma are diagnosed in the United States. While this is just a small percentage of overall cancer diagnoses, this rare cancer is one that has proven to be extremely difficult to treat. Fortunately, even with this cancer affecting a disproportionate number of patients, researchers are continuing to study mesothelioma in hopes of improving the disease’s prognosis.  Discuss
Landmark study explores public understanding of science and trust in scientific and medical professionals
Understanding global perceptions and knowledge of science is of growing interest to the scientific community. Organizations such as 3M, with their State of Science Index Survey and the Wellcome Global Monitor (WGM), from the Wellcome Foundation and Gallup World Poll, explore attitudes towards science and medicine, and also confidence in scientists themselves.  Discuss
Leaders in science and engineering publications over the last decade: China and the US
Capturing the attention of policy makers and companies serving the academic research market the countries with the largest number of science and engineering (S&E) articles has significantly evolved between 2007 and 2017. China leads the list in 2017 followed by the US, a reverse from 2007, according to a May report from the NSF’s National Center for Science and Engineering Statistics.  Discuss
Conferences
2020 ACCP Annual Meeting
September 20-22
Bethesda, Maryland United States
Bioprocess International West
September 21-24
Eastern Standard Time Zone (EST) United States
BioProcess International
September 21-24
Eastern Standard Time Zone (EST), Massachusetts United States
General Discussion
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