Loss of protective protein linked to age-related changes in the eye
A study in mice has shown that the loss of a protein that protects retinal support cells may drive aging-associated diseases of the retina such as macular degeneration. Read More
Study shows potential of CRISPR-Cas9 tools for synthetic gene control, cellular engineering
Rice University researchers were able to use deactivated Cas9 (dCas9) proteins to target key segments of the human genome to synthetically trigger the transcription of human genes. Using dCas9 proteins, researchers have revealed important details about human promoters and enhancers. Read More
Single-cell analyses shed light on drug resistance of melanoma brain metastases
Using single-cell genetic analyses of frozen brain samples, Columbia University researchers have uncovered evidence of how melanoma brain metastases evade current treatments. Read More
Ribosome profiling expands pool of potentially protein-coding regions of DNA
Using ribosome profiling, researchers from 20 institutions worldwide have identified more than 7,200 previously unrecognized gene segments of the human genome that may code for new proteins. Read More
CRISPR reveals interconnected map of immune feedback loops, regulatory networks
The disruption of thousands of genes using CRISPR-Cas9 gene editing has revealed a map of how human immune cells function. The resulting map could reveal the collections of genes that need to function properly to prevent immune diseases. Read More
Single-cell sequencing finds subset of CAR T cells that drive anticancer effects
A small subset of the CAR T cells prepared for therapy produce most of the anticancer activity, suggesting it may be possible to improve the treatment, according to a study published in the journal Cancer Discovery. Read More
Large DNA insertions in CRISPR-edited cells could increase cancer risk: study
CRISPR-Cas9 can cause large rearrangements of DNA through retrotransposition to theoretically trigger tumor development, according to a paper published in Nature Communications. Read More
Plant-microbe biology study uncovers trigger for tumor growth in humans
Targeting the plasminogen-apple-nematode domain can block cell proliferation, pointing to the potential to treat certain cancers, according to a paper published in the journal Communications Biology. Read More
Global consortium creates 'largest' zebrafish genetic atlas to support human disease research
An international consortium of 27 laboratories called DANIO-CODE has created an atlas of genetic data on zebrafish to support research into conditions including cancer, heart disease, and neurodegeneration. Read More
Single DNA strand cuts achieve safety and efficacy edge over CRISPR-Cas9 in fruit flies
CRISPR-Cas9 variants known as “nickases” that target a single DNA strand may increase the success rate of gene editing and reduce the risk of off-target mutations, according to a paper published in the journal Science Advances. Read More
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