Drug Discovery & Development
Experts map the future of bioprinting
Bioprinting has rapidly advanced in both techniques and clinical applications, but key challenges still remain for the burgeoning field. A multinational team of researchers offered their recommendations for how to address these hurdles in an in-depth road map article published February 7 in Biofabrication. Read More
Hydrogels enable on-demand production of pharmaceuticals
A first-in-class system that effectively embeds engineered microbes into the solid support of a 3D-printed hydrogel is described in a report published in Nature Communications on February 4. The hydrogel system organizes both individual microbes and groups of microbes for on-demand production of pharmaceuticals. Read More
Math models improve the effectiveness of immunotherapy
Scientists working at the intersection of math and medicine propose new strategies based on mathematical modeling and known molecular mechanisms to improve the efficacy of lifesaving immunotherapies for cancerous tumors. The work was published on February 3 in the Proceedings of the National Academy of Sciences. Read More
Nanoparticles eat cardiovascular plaques from the inside out
Scientists have engineered a nanoparticle that eats plaques associated with cardiovascular disease -- from the inside out. This Trojan horse technology could offer a new therapeutic option for the treatment of atherosclerosis, according to a study published in Nature Nanotechnology on January 27. Read More
Stem cell findings help researchers learn about early-onset Parkinson's
New research utilizing stem cells indicates that the metabolic processes that lead to young-onset Parkinson's disease could begin years before symptoms of the disease emerge. But the findings also point to a potential drug candidate that could be used to treat the condition, according to a study published January 27 in Nature Medicine. Read More
New study offers hope for short-circuiting KRAS-driven lung cancers
The protein kinase p38α has been identified as a key element supporting KRAS-driven lung cancers, so inhibiting the protein has potential as a target for the treatment of certain lung cancers. An international group of researchers used genetic mouse models with the KRAS mutation to observe how p38α inhibition reduces tumor growth. The work was published in the Proceedings of the National Academy of Sciences on January 22. Read More
Small-molecule chaperones may reverse Alzheimer's symptoms in mice
A novel treatment for Alzheimer's disease involving the administration of pharmacological chaperones that prevent amyloid beta and tau tangles from forming in the brain may be possible, according to a new study published online on January 22 in Molecular Neurodegeneration. Read More
Scientists in the Lab: Featuring Rajan Chaudhari
We are thrilled to introduce our next laboratory scientist this month, who works at the intersection of chemistry, drug development, and data science. Rajan Chaudhari, PhD, is a postdoctoral fellow at the University of Texas MD Anderson Cancer Center in Houston. Read More
Researchers tackle fake medicine with uncrackable puzzles
Protecting patients from consuming counterfeit medicines is an urgent need. A new uncrackable authentication system is being developed with the use of degradable fluorescent proteins. Researchers from Purdue University are developing edible "security tags" that can be embedded on medicines. The work was published in Nature Communications on January 16. Read More
Scientists learn how lactate contributes to cancer formation
Previously considered a waste product of metabolism, lactate may play a crucial role in cancer growth, according to a study published in Frontiers in Oncology on January 14. Researchers from the University of Colorado Anschutz Medical Campus explored how lactate affects transcription of oncogenes in breast cancer cells. Read More
Conferences
Interphex 2021
October 19-21
New York City, New York United States
Building Biology in 3D Hybrid Symposium
October 26-27
La Jolla, California United States
Northeast Regional Laboratory Staff and Core Directors (NERLSCD) 2021
November 3-5
Portsmouth, New Hampshire United States
CPhI Worldwide 2021
November 9-11
Milan, Lombardia Italy
Society for Immunotherapy of Cancer (SITC) Annual Meeting
November 10-14
Washington, DC, District of Columbia United States
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