Sugar alters microbiome, leads to metabolic disease, prediabetes, obesity in mice
August 30, 2022 -- Researchers led by Columbia University have investigated the effects of the Western-style high-fat, high-sugar diet on mice and found that while diet matters, an optimal microbiome is equally important for the prevention of metabolic syndrome, diabetes, and obesity. Read More
Oral delivery of lipid nanoparticles effective for ulcerative colitis in mice
August 29, 2022 -- Georgia State University researchers have discovered a new way to treat ulcerative colitis -- oral delivery of lipid nanoparticles that target the colon with nucleic acids. Read More
New treatment from Sweden for hepatitis B, D shows promise in mice
August 29, 2022 -- Researchers at Karolinska Institutet in Sweden have developed a new type of treatment for chronic hepatitis B virus and hepatitis D virus infections that may provide a lasting treatment response. Read More
ElevateBio, University of Pittsburgh awarded $100M grant to create biomanufacturing center
August 26, 2022 -- ElevateBio and the University of Pittsburgh have been awarded a $100 million grant from the Richard King Mellon Foundation to create the Pitt BioForge BioManufacturing Center at Hazelwood Green in Pittsburgh. Read More
Nonviral CRISPR approach simplifies reengineering of large quantities of cells for therapeutics
August 25, 2022 -- Scientists at the Gladstone Institutes and the University of California, San Francisco have developed a new approach using CRISPR-Cas9 gene editing to produce massive quantities of cells for therapeutic applications. Read More
Researchers identify biomarkers resistant to chemotherapy in triple-negative breast cancer
August 25, 2022 -- Researchers have discovered the biological markers in triple-negative breast cancer that are associated with resistance to chemotherapy. Read More
Clearing toxic waste from mice brains offers hope for Alzheimer’s, other diseases
August 25, 2022 -- Researchers have found a way to increase the clearance of waste products such as amyloid beta from the brains of mice by ramping up a genetic quirk known as readthrough. The same strategy could be effective for neurodegenerative conditions characterized by the buildup of toxic proteins, such as Alzheimer’s disease. Read More
Gensaic, Ovid Therapeutics partner on phage-derived gene therapies for CNS
August 25, 2022 -- Gensaic is collaborating with Ovid Therapeutics to develop up to three genetic medicines for central nervous system (CNS) disorders using its proprietary phage-derived particle platform. Read More
Roche launches its first digital PCR for cancer, other diseases
August 24, 2022 -- Diagnostics company Roche has launched its first digital polymerase chain reaction (PCR) system, designed to accurately quantify trace amounts of specific DNA and RNA targets not typically detectable by traditional PCR technology. Read More
Common molecular tool for DNA labeling has surprising anticancer properties
August 23, 2022 -- Scientists at the University of North Carolina School of Medicine have discovered that a molecule called EdU (5-ethynyl-2'-deoxyuridine), a common molecular tool for DNA labeling, has surprising anticancer properties that warrant further investigation. Read More
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