Sengenics offers COVID-19 antigens for vaccine development

By The Science Advisory Board staff writers

March 13, 2020 -- Sengenics announced that it has COVID-19 antigens available for both research and commercial vaccine development purposes for sale.

The company has successfully developed properly folded and functional COVID-19 antigens using its patented KREX technology. The development of these antigens was expedited by increasing numbers of COVID-19 infections, which are needed to develop vaccines and further characterize the SARS-CoV-2 virus.

The folded structure of a protein antigen is a key component of antibody recognition, according to Jonathan Blackburn, PhD, chief scientific officer of Sengenics, in a statement. A protein's antigenic property is dependent on efficient epitope presentation and subsequent stimulation of B and T cells, he noted.

But since most antibodies are thought to recognize discontinuous epitopes on their target proteins, Blackburn believes it's critical that antigens used in serological assays or presented to B cells for antibody-based vaccine development are in a natively folded form.

"The use of our KREX technology for the production of the SARS-CoV-2 antigens will ensure these antigens are correctly folded, preserving all conformational antibody binding sites, and that they are highly purified, free from bacterial contaminants, ready for downstream applications," Blackburn stated in a press release.

Dante Labs offers free whole-genome sequencing services to scientists
Dante Labs, an Italy-based commercial genomics laboratory, announced it has started a program to support global scientific research on the novel coronavirus....
Breakthrough in coronavirus research provides map for vaccines
Critical research reveals the 3D atomic-scale map of the spike protein of the 2019 novel coronavirus (2019-nCoV), which is responsible for infecting humans....
Arbor offers NGS coronavirus panel to researchers for free
Arbor Biosciences announced on February 12 that it will release its myBaits Expert hybridization-based panel for detecting infection with the 2019 novel...

Copyright © 2020 scienceboard.net


Register below for our weekly Letter from the Editor to receive the latest Science news and insights.
Email
Conferences
Experimental Biology 2020
April 4
San Diego, California United States
BioProcess International Europe
April 28 - May 1
Amsterdam, Noord-Holland Netherlands
Lab of the Future USA
May 19-20
Boston, Massachusetts United States
2nd Annual Cell Therapy Bioprocessing Conference
June 25-26
Boston, Massachusetts United States
BioProcess International
September 21-24
Boston, Massachusetts United States
Connect
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter