Critical inhibitory site in enzyme leads to new antibiotic
Japanese researchers have discovered a new mechanism to allosterically inhibit a respiratory chain enzyme widely conserved across species. The research, published December 8 in the journal Nature Communications, identified an antibiotic effective against a drug-resistant strain of Neisseria gonorrhoeae based on their findings. Read More
Cellular nano-chamber directs tubulin protein folding: study
U.S. Department of Energy and Stanford University researchers have revealed how tiny cellular machines -- called chaperonins -- direct the folding of proteins into building blocks that provide essential cellular scaffolding and transport. Read More
Optogenetics-based tool manipulates neuron excitability
Harvard University and Massachusetts Institute of Technology researchers have devised a new technique to achieve long-term changes in neuron activity using light exposure. Their research, published on December 7 in the journal Science Advances, may help establish causality between neuron excitability and behavior, advancing the field of optogenetics. Read More
Scientists create cell atlas of developing human lung
Researchers from the Wellcome Sanger Institute, EMBL’s European Bioinformatics Institute, the Gordone Institute at the University of Cambridge, and collaborators have created a spatiotemporal cell atlas of the developing human lung. From the mapping, they have identified 144 cell states in the early stages of life and their interactions in new detail. Read More
New microscopy captures 3D images of whole organisms
A new microscopy technique enhances biomedical research by capturing dynamic 3D images across larger areas while maintaining cellular resolution in all three dimensions. A study, published on December 8 in the journal Optica, provides new views of cells interacting in their natural state, potentially facilitating the development of new disease treatments. Read More
Machine learning used to encode commands for immune cells
Researchers at University of California San Francisco (UCSF), in collaboration with a team at IBM Research, have developed a virtual molecular library of thousands of “command sentences” for cells, based on combinations of “words” that guide engineered immune cells to seek out and kill cancer cells without pausing. Read More
Vegetables contain ‘garden variety’ cancer drugs
Polish scientists have revealed the potential for new cancer drugs formulated from nightshade plants (genus Solanum), including potatoes and eggplants. Read More
New drug 'fakes out' SARS-CoV-2 to neutralize it
A new drug neutralizes SARS-CoV-2 and its variants by acting as an ACE2 receptor decoy, Dana-Farber Cancer Institute researchers revealed. Read More
Scientists manufacture malaria sporozoites without mosquitoes
Sanaria scientists have manufactured Plasmodium falciparum (Pf) sporozoites (SPZ) in vitro, enabling the critical, first breakthrough steps to scale up manufacturing of the PfSPZ malaria vaccine. Read More
USC researchers create 'heart attack on a chip'
University of Southern California (USC) researchers have developed a "heart attack on a chip" that replicates key aspects of myocardial infarction and might one day serve as a testbed for new personalized heart drugs. Read More
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