New technique could enable production of generic CAR T cells at scale
A Boston Children’s Hospital lab has developed a new method that could make chimeric antigen receptor (CAR) T-cell therapy more widely available using induced pluripotent stem cells to develop mature immune cells. Read More
NIH awards grants to launch experimental science rigor initiative
The National Institutes of Health (NIH) has awarded five new grants to launch an initiative designed to support education in the principles of rigorous scientific research. Read More
Exposure to cold inhibits cancer growth in mice: study
The exposure of tumor-bearing mice to cold conditions markedly inhibited the growth of various types of solid tumors, according to a new study by researchers at Sweden’s Karolinska Institutet. Read More
Spanish researchers identify protein driving melanoma malignancy
Several proteins are involved in the progression of melanoma, and one in particular, PDIA6, drives malignancy, researchers at the Centre for Genomic Regulation in Barcelona found. Read More
New technique visualizes cells less than 10 nm
A new photoswitching fingerprint analysis enables the optical imaging of dynamic interactions with other molecules in the cell. The analysis reliably allows for structural optical resolution in cells in the sub-10 nm range. Read More
Seer debuts new proteomic-mapping software
Seer has launched a new Proteogenomics Workflow that integrates deep proteomics with genomics and is powered by the Proteograph Analysis Suite 2.0. Read More
Thermo Fisher, Structura Biotechnology unveil particle analysis software
Thermo Fisher Scientific and Structura Biotechnology are partnering together on a new, single particle analysis software. The software will be a version of Structura's CryoSparc Live and will integrate with Thermo Fisher's Smart EPU software and cryo-transmission electron microscope technology. Read More
Gene therapy shows promise in treating ALS in rodent models
A gene therapy, patented through the University of California, San Diego and the Department of Veterans Affairs measurably delayed disease onset in humanized mouse and rat models of familial amyotrophic lateral sclerosis (ALS). Read More
Thymus uses RNA molecules to generate list of friendly proteins that T cells should not attack
Research from Cold Spring Harbor Laboratory has identified the RNA molecules used by the human thymus organ to generate a list of friendly proteins that T cells should not attack, a discovery which may lead to improved immunotherapies and treatments for autoimmune disorders and cancer. Read More
Mice deficient in DCIR are resilient against colitis, colonic tumor growth
Using mice models, researchers from Japan and China have shown that dendritic cell immunoreceptor (DCIR) protein deficiency is resistant to colonic tumors induced by dextran sodium sulfate and azoxymethane, while identifying an antibody that reduces colitis severity and colonic tumor growth. Read More
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