Molecule inhibits drug-resistant bacteria in mice with pneumonia, UTIs
August 10, 2022 -- A new molecule that inhibits drug-resistant bacteria in laboratory experiments, as well as in mice with pneumonia and urinary tract infections (UTIs), has potential for treating stubborn infections in humans, according to researchers. Read More
Exhausted T cells can be resurrected
August 8, 2022 -- Even the most exhausted T cells can be revived, according to University of Pittsburgh and University of Pittsburgh Medical Center researchers. Previously, it was thought when T cells reached a certain stage of exhaustion they were done, but a study published August 5 in Science Immunology shows that’s not the case. Read More
New technique could enable production of generic CAR T cells at scale
August 4, 2022 -- A Boston Children’s Hospital lab has developed a new method that could make chimeric antigen receptor (CAR) T-cell therapy more widely available using induced pluripotent stem cells to develop mature immune cells. Read More
Thymus uses RNA molecules to generate list of friendly proteins that T cells should not attack
August 2, 2022 -- Research from Cold Spring Harbor Laboratory has identified the RNA molecules used by the human thymus organ to generate a list of friendly proteins that T cells should not attack, a discovery which may lead to improved immunotherapies and treatments for autoimmune disorders and cancer. Read More
Mice deficient in DCIR are resilient against colitis, colonic tumor growth
August 2, 2022 -- Using mice models, researchers from Japan and China have shown that dendritic cell immunoreceptor (DCIR) protein deficiency is resistant to colonic tumors induced by dextran sodium sulfate and azoxymethane, while identifying an antibody that reduces colitis severity and colonic tumor growth. Read More
Researchers discover what drives T cells to protect the gut
August 1, 2022 -- New research finds the barrier cells that line the intestines send messages to the patrolling T cells that reside there by expressing the HVEM protein. That signaling prompts T cells to survive longer and move more to stop potential infections. Read More
Intranasal COVID-19 vaccine tops vaccine injection
July 28, 2022 -- Ohio researchers have discovered a new way of delivering the COVID-19 vaccine: up the nose. It could one day be incorporated into the existing measles-mumps-rubella vaccine as a way to produce COVID-19 immunity in kids. Read More
Scientists safely add fluorine to drugs
July 28, 2022 -- An international team of scientists have found how to add the fluorine atom to macrolide antibiotics, which means not only changes in the final product’s structure, but also the ability to kill bacteria and work safely in patients. Read More
AACC sees rise in impact of medical laboratory journal
July 21, 2022 -- AACC recently announced that the impact factor of its journal Clinical Chemistry has risen to 12.167 in the 2021 Clarivate Journal Citation Reports. Read More
Nanoparticles-vaccine combination kills melanoma cancer cells
July 21, 2022 -- Charged nanoparticles combined with a vaccine are effective in eliminating melanoma tumors or extending the life span of cancerous mice, according to a study published July 20 in the journal Science Advances. Read More
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