New antibody neutralizes all known SARS-CoV-2 variants: study

By The Science Advisory Board staff writers

August 12, 2022 -- An antibody developed at Boston Children’s Hospital neutralizes all known SARS-CoV-2 variants, including omicron subvariants, which may inform the design of future COVID-19 vaccines.

The SP1-77 antibody binds the spike protein at a site that so far has not been mutated in any SARS-CoV-2 variant, broadly neutralizing current variants by a novel mechanism and providing valuable insights for the development of vaccines, according to researchers.

Writing in an August 11 article in Science Immunology, the researchers discuss the broadly neutralizing SP1-77 antibody and their humanized mouse model, which may contribute to identifying therapeutic antibodies against future SARS-CoV-2 variants and other pathogens.

"We hope that this humanized antibody will prove to be as effective at neutralizing SARS-CoV-2 in patients as it has proven to be thus far in preclinical evaluations," Frederick Alt, PhD, from the Program in Cellular and Molecular Medicine at Boston Children's Hospital, who co-led the study, said in a statement.

In related news this week, scientists from Scripps Research reported on August 10 in Science Translational Medicine that they discovered certain antibodies capable of immunity against many different SARS-CoV-2 variants, as well as other SARS viruses like SARS-CoV-1.

Certain animals are more capable of producing these broad antibodies and during their investigation, the study team identified the antibody structures that provide this more comprehensive immune response, which has implications for vaccine production.

In the study, rhesus macaque monkeys were immunized with the SARS-CoV-2 spike protein and two vaccine shots were administered that resemble the current mRNA vaccines available for humans. However, unlike humans, the monkeys had a broad neutralizing antibody response against the virus due to their antibodies recognizing the conserved region, in this case the angiotensin converting enzyme 2 receptor binding site.

Antibodies create broad SARS immune response: study
Scientists from Scripps Research have discovered certain antibodies are capable of immunity against many different SARS-CoV-2 variants, as well as other...
Studies uncover findings on antibody responses, immunity
Findings from two studies add to a growing body of knowledge that is essential for guiding public health initiatives and might one day enable clinicians...
Current COVID-19 boosters provide protections against serious infection: study
Despite the evolution of the SARS-CoV-2 pandemic coronavirus, a new laboratory study conducted by a team of international researchers suggests current...

Copyright © 2022 scienceboard.net


Conferences
Laboratory Products Association Annual Meeting
October 1-4
Scottsdale, Arizona United States
Cell & Gene Meeting on the Mesa
October 11-13
Carlsbad, California United States
IDWeek 2022
October 19-23
District of Columbia United States
American Society of Human Genetics Annual Meeting
October 25-29
Los Angeles, California United States
Connect
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter