Immatics to highlight ACTengine program updates at SITC

By The Science Advisory Board staff writers

November 1, 2021 -- Immatics plans to offer an update on its ACTengine IMA203 trial at the upcoming Society for Immunotherapy of Cancer (SITC) 2021 annual meeting in Washington, DC, November 12-13.

The company's ACTengine is a next-generation CD8ab T-cell receptor T-cell (TCR-T) approach used to develop T cell-redirecting cancer immunotherapies. The approach uses a patient's own T cells that are genetically engineered to express a novel, proprietary T-cell receptor directed against a defined cancer target. The modified T cells are then reinfused into the patient to attack the tumor, an approach also known as TCR-T.

The update will be delivered by Dr. Martin Wermke of the University Hospital Carl Gustav Carus in Dresden, Germany, in a presentation titled "Safety and Anti-Tumor Activity of TCR-Engineered Autologous, PRAME-Directed T Cells Across Multiple Advanced Solid Cancers at Low Doses," according to Immatics.

A second presentation delivered by the company's director of process development, Mamta Kalra, PhD, will update attendees on the company's next-generation CD8ab TCR-T approach, it said.

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