Artiva, Merck to develop CAR NK cell therapies

By The Science Advisory Board staff writers

January 28, 2021 -- Artiva Biotherapeutics and Merck have signed an agreement to develop chimeric antigen receptor (CAR) natural killer (NK) cell therapeutics for solid tumors.

Under terms of the deal, the firms will use Artiva's allogenic NK cell manufacturing platform and CAR-NK technology to develop two CAR-NK therapies with an option for a third, which Merck will then clinically develop and market. Artiva will receive an upfront payment of $30 million for first two therapies, $15 million if Merck requests a third, and up to $612 million in future development and commercial milestones and royalties on product sales, the two companies said.

Artiva's current CAR-NK offerings include AB-201 for the treatment of HER2+ solid tumors and AB-202 for the treatment of B-cell malignancies, it said.

Merck discontinues work on COVID-19 vaccines to focus on therapeutics
Merck will discontinue development of its COVID-19 vaccine candidates because they produced a lower immune response compared to natural infection or other...
Janux, Merck partner on T-cell engager immunotherapies
Janux Therapeutics has entered into a strategic collaboration and licensing agreement with Merck to discover, develop, and commercialize next-generation...
Merck KGaA, Artios partner on DNA damage response drugs
Artios Pharma and Merck KGaA are set to develop multiple cancer drugs aimed at DNA damage response pathways through a new three-year long research and...
Cue Biopharma, Merck expand Immuno-STAT collaboration
Cue Biopharma has extended the terms of its research collaboration and license agreement with Merck toward developing new clinical candidates for the...
Iktos, Merck collaborate on AI for new drug designs
Artificial intelligence (AI) firm Iktos plans to collaborate with pharmaceutical giant Merck on AI for new drug design.

Copyright © 2021

Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter