October 26, 2022 -- On-Demand Webinar -- Chromatin regulatory networks integrate genetic and environmental factors to facilitate gene expression programs, which are essential for normal cellular function. Defective chromatin signaling alters gene expression and is strongly linked to developmental disorders and disease.
Chromatin immunoprecipitation followed by next-generation sequencing (ChIP-seq) provided a foundational method to study chromatin structure by mapping the location of histone post-translational modifications (PTMs) and chromatin-binding proteins genome-wide. However, the innate challenges of ChIP-seq -- including poor sensitivity, low throughput, and high costs -- have severely limited the application of chromatin profiling, particularly as it relates to the study of rare/precious cell populations, drug development, and biomarker discovery.
But, there is a solution. By utilizing a novel in situ strategy that enables unprecedented mapping sensitivity and simplified workflows, CUT&RUN and CUT&Tag are creating a paradigm shift in epigenomics research. This presentation will illustrate how these scalable technologies unlock the full potential of epigenomics for next-generation chromatin studies.