Genome & Company doses patients in immuno-oncology microbiome therapeutic trial

By The Science Advisory Board staff writers

October 27, 2020 -- Genome & Company has initiated clinical testing of GEN-001, an anti-cancer microbiome therapeutic, six months after its investigational new drug approval.

The phase Ib clinical trial will evaluate the oral microbiology therapy candidate in combination with avelumab (Bavencio), an anti-programmed cell death ligand 1 (PD-L1) checkpoint inhibitor in patients with a variety of solid tumors. Bavencio is being jointly developed by Merck and Pfizer.

A total of three trial centers including Oregon Health and Science University Knight Cancer Institute will complete the dose escalation cohort in the first half of 2021.

Under the agreement, Genome & Company will sponsor the study and Merck and Pfizer will supply Bavencio for the phase I/IB clinical trial.

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