Immunic begins phase II immunotherapy for COVID-19

By The Science Advisory Board staff writers

June 15, 2020 -- Immunic has enrolled the first COVID-19 patients in a phase II clinical trial of IMU-838, a selective oral dihydroorotate dehydrogenase (DHODH) inhibitor.

Approximately 230 patients will be enrolled in 10 to 35 centers in the U.S., Germany, and other European countries. The study will be a prospective, multicenter, randomized, placebo-controlled, double-blind clinical trial in patients with moderate COVID-19, designed to evaluate efficacy, safety, and tolerability of IMU-838. Data is expected to be available later this year.

To date, IMU-838 has already been tested in about 650 individuals in previous studies.

IMU-838 is an orally available, next-generation selective immune modulator that inhibits intracellular metabolism of activated immune cells (T and B cells) by blocking the DHODH enzyme. The molecule has also been shown to possess antiviral effects, independent of specific viral proteins, indicating that it may be broadly applicable against multiple viruses.

IMU-838 is also being tested for treatment of relapsing-remitting multiple sclerosis, ulcerative colitis, and Crohn's disease.


Copyright © 2020 scienceboard.net


Register below for our weekly Letter from the Editor to receive the latest Science news and insights.
Email
Conferences
Festival of Genomics & Biodata
January 28-29, 2021
London, Greater London United Kingdom
Lab of the Future USA
May 11-12, 2021
Boston, Massachusetts United States
Connect
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter