Scientists capture first image of antigen-bound T-cell receptor at atomic resolution

By The Science Advisory Board staff writers

August 18, 2022 -- Using cryo-electron microscopy (cryo-EM), scientists from Goethe University Frankfurt (in collaboration with the University of Oxford and the Max Planck Institute of Biophysics) have for the first time been able to visualize the whole T-cell receptor (TCR) complex with bound antigen at atomic resolution.

Writing in an August 18 article in the journal Cell, the authors noted that comparisons of the ligand-bound and unliganded receptors -- along with molecular dynamics simulations -- indicate that T-cell receptors can be triggered in the absence of spontaneous structural rearrangements.

The researchers contend that the cryo-EM structure of the fully assembled TCR complex with a tumor-associated peptide/major histocompatibility complex (MHC) ligand provides important insights into the biology of TCR signaling, helping to understand a fundamental process which may pave the way for novel therapeutic approaches targeting severe diseases.

"Our structure is a blueprint for future studies on T-cell activation," Robert Tampé, PhD, director of the Institute of Biochemistry at Goethe University Frankfurt, said in a statement. "In addition, it's an important stimulus for employing the T-cell receptor in a therapeutic context for treating infections, cancer, and autoimmune diseases."

Repertoire, Yale partner to study T-cell contributions to MS
Repertoire Immune Medicines is collaborating with Yale University to understand the basis of cellular immunity of multiple sclerosis (MS) by determining...
T-Cure, Rutgers to collaborate on T-cell receptor cancer therapies
T-Cure Bioscience has inked an agreement with Rutgers University in New Brunswick, NJ, to collaborate on research into T-cell receptor therapy for cancer...
New method creates insights into T-cell responses to infections
Researchers have developed a method to study the specialization of T cells in the context of acute versus chronic infections. They found that T-cell responses...

Copyright © 2022

Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter