Scientists discover new pathway to treat glioblastoma

By The Science Advisory Board staff writers

July 25, 2022 -- Researchers have developed a biomimetic formulation using nanoparticles for lactate metabolism-based synergistic therapy to fight against the brain cancer glioblastoma multiforme (GBM).

The Institute of Process Engineering of the Chinese Academy of Sciences and Shenzhen Second People's Hospital collected 524 low-glioma samples and 167 high-grade glioma samples (Nature Communications, July 21, 2022). By encasing the nanoparticles in membranes derived from glioma cells, they readily penetrated the blood-brain barrier and targeted GBM through homotypic recognition.

Once the nanoparticles reach the tumors, lactate oxidase converts elevated lactate (LA) into pyruvic acid (PA) and hydrogen peroxide (H2O2). The PA inhibits cancer cell growth by blocking histones expression and inducing cell-cycle arrest. In tandem, the H2O2 reacts with the delivered bis[2,4,5-trichloro-6-(pentyloxycarbonyl)phenyl] oxalate to release energy that is used by the co-delivered photosensitizer chlorin e6 for the generation of cytotoxic singlet oxygen to kill glioma cells.

The therapeutic efficacy was confirmed in both cell line-derived xenograft and patient-derived xenograft tumor models and has implications for clinical application, the researchers said.

Plant-microbe biology study uncovers trigger for tumor growth in humans
Targeting the plasminogen-apple-nematode domain can block cell proliferation, pointing to the potential to treat certain cancers, according to a paper...
Researchers find how EGFR sends signals into cells, could help cancer drug design
Chemists at the Massachusetts Institute of Technology have revealed how the epidermal growth factor receptor (EGFR) changes its shape when it binds to...
Genenta Science reports preliminary results of Temferon-glioblastoma study
Biotech company Genenta Science is developing a proprietary hematopoietic stem cell gene therapy, Temferon, for the treatment of a variety of solid tumor...
Endosomal pH drives stemness in glioblastoma
A group of researchers has shown that endosomal pH drives stemness in glioblastoma. The group discovered that endosomal Na+/H+ exchanger isoform 9 is...
Researchers create 3D tumor models with cells from patients
Using tissue samples from cancer patients, Israeli researchers have successfully printed an active, viable glioblastoma 3D tumor model. In addition to...

Copyright © 2022 scienceboard.net


Conferences
Glasgow International Health Festival
August 24-27
Glasgow, Glasgow City United Kingdom
Pharma Competitive Intelligence Conference and Exhibition
September 21-22
Newark, New Jersey United States
BioProcess International (BPI) Conference
September 27-30
Boston, Massachusetts United States
Laboratory Products Association Annual Meeting
October 1-4
Scottsdale, Arizona United States
Connect
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter