NIH study shows how immune response to COVID-19 damages the brain

By The Science Advisory Board staff writers

July 5, 2022 -- A National Institutes of Health (NIH) study, which examined brain changes in nine people who died suddenly after contracting COVID-19, found that antibodies are involved in the attack on cells lining the brain's blood vessels, leading to inflammation and damage.

NIH researchers discovered that SARS-CoV-2 infection triggers the production of immune molecules that damage endothelial cells lining blood vessels in the brain, causing platelets to stick together and form clots. In addition, blood proteins leak from the blood vessels causing neuroinflammation and the destruction of neurons.

"Patients often develop neurological complications with COVID-19, but the underlying pathophysiological process is not well understood," said Dr. Avindra Nath, senior author of the study and clinical director at National Institute of Neurological Disorders and Stroke. "We had previously shown blood vessel damage and inflammation in patients' brains at autopsy, but we didn't understand the cause of the damage."

Nath said that the study, published on July 5 in the journal Brain, has provided "important insight into the cascade of events" leading to COVID-19 neurological complications and suggest that treatments designed to prevent the development of the immune complexes could be potential therapies.

Eli Lilly's bebtelovimab receives EUA for mild-to-moderate COVID-19
The U.S. Food and Drug Administration issued an emergency use authorization (EUA) for Eli Lilly's antibody bebtelovimab, which demonstrates neutralization...
IsoPlexis uses proteomics to identify early factors of long COVID
IsoPlexis has published a study in Cell, led by the Institute for Systems Biology and the Seattle COVID Consortium, in which researchers used...
FDA expands use of remdesivir to outpatients with mild-to-moderate COVID-19
The U.S. Food and Drug Administration (FDA) has expanded the use of the antiviral drug Veklury (remdesivir) to certain nonhospitalized adults and pediatric...

Copyright © 2022

Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter