Immunoprecise highlights combo neutralization of antibodies

By The Science Advisory Board staff writers

July 31, 2020 -- Immunoprecise Antibodies has conducted additional characterization of a subset of fully human, therapeutic SARS-CoV-2 antibodies that are potent and exhibit enhanced neutralization upon combinatorial testing.

Previously, the company demonstrated potent in vitro neutralizing activity of functional antibodies discovered using its DeepDisplay phage technology, B Cell Select, and single-step hybridoma platforms. Now, the company has confirmed that six antibodies covering three epitopes analyzed for enhanced function in combination studies resulted in near complete SARS-CoV-2 pseudovirus infection.

Efforts continue to further analyze multiple additional subsets of antibodies including neutralizing antibodies that bind to the S1 and S2 subunit domains of the SARS-CoV-2 spike protein. The company has begun steps for expression of the lead antibodies for preclinical and clinical manufacturing.

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