Thermo Fisher to develop, manufacture next-gen immunotherapy

By The Science Advisory Board staff writers

June 10, 2020 -- Thermo Fisher Scientific has formed a strategic partnership with PharmAbcine for the development and manufacturing of PMC-309, a next-generation immune checkpoint blockade to treat cancer.

Under the agreement, PharmAbcine will use Thermo Fisher's Quick to Clinic integrated service offering, a program that accelerates drug development for investigational new drug (IND) submissions for phase I clinical trials.

PMC-309 is a fully human monoclonal antibody (immunoglobulin G) that targets the epitope of human V-domain immunoglobulin suppressor of T-cell activation (VISTA) that is primarily expressed on myeloid-derived suppressor cells. Inhibition of VISTA-positive immunosuppression is a promising immunotherapeutic strategy and an alternative to PD1/PDL1 targeting immuno-oncology drugs.

The drug will be developed at Thermo Fisher's site in Princeton, NJ, and PharmAbcine plans to initiate IND-enabling studies this year and submit global IND in 2021.

Sloan Kettering, Hackensack form immunology collaboration
Memorial Sloan Kettering and Hackensack Meridian Health have formed an immunology research collaboration to support cancer immunotherapy research.
Thermo Fisher to operate new CSL biologics facility
Thermo Fisher Scientific has entered into a long-term lease agreement with CSL to operate a new biologics manufacturing facility in Lengnau, Switzerland.
Thermo releases spectrometry products for proteomics
Thermo Fisher Scientific has announced an exclusive license agreement with software firm MSAID for intelligent software that uses deep learning facilitated...
Thermo Fisher to double viral vector manufacturing capacity
Thermo Fisher Scientific is expanding its viral vector development and manufacturing services with construction of a new commercial manufacturing site...
AGC Biologics, Faron to manufacture cancer immunotherapy
Contract development and manufacturing organization AGC Biologics has formed a cancer immunotherapy partnership with Faron Pharmaceuticals.

Copyright © 2020

Microscopy and Microanalysis Meeting
July 31 - August 4
Portland, Oregon United States
Glasgow International Health Festival
August 24-27
Glasgow, Glasgow City United Kingdom
Pharma Competitive Intelligence Conference and Exhibition
September 21-22
Newark, New Jersey United States
BioProcess International (BPI) Conference
September 27-30
Boston, Massachusetts United States
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter