The inner ear complex that converts vibrations into electrical impulses that the brain translates as sound is known as the mechanosensory transduction complex. This process is responsible for the sensations of balance and sound. However, its molecular basis has long been unclear.

Hearing loss, which affects more than 460 million people worldwide, can be inherited through gene mutations that alter the proteins comprising the mechanosensory transduction complex. Alternatively, it can occur from damage, including sustained exposure to loud noise.

The nematode, or roundworm(Caenorhabditis elegans), fortuitously harbors a mechanosensory transduction complex very similar to humans. The researchers spent five years painstakingly optimizing their worm-growth and protein-isolation methods, eventually utilizing 60 million worms, along with state-of-the-art cryo-electron imaging -- available at only three cryo-electron microscopy centers in the U.S. Their work revealed the structure of a mechanically sensitive protein complex in the roundworms, illuminating the architecture of the machinery that translates mechanical forces into electrical signals.

"The auditory neuroscience field has been waiting for these results for decades, and now that they are right here, we are ecstatic," OHSU research scientist Peter Barr-Gillespie, PhD, said in a statement. "The results from this paper immediately suggest new avenues of research, and so will invigorate the field for years to come."

Study of antibiotic-caused hearing loss identifies potential therapeutic targets
Indiana University School of Medicine researchers used mouse laboratory models to study how aminoglycoside antibiotics may cause human hair cell death...

Researchers identify transcription factors that restore hearing in zebrafish
Certain transcription factors were able to restore hearing in zebrafish through cell regeneration and could inform treatments for hearing loss in humans,...

New cryo-EM tool visualizes biomolecules at near-atomic level
German researchers have used cryo-electron microscopy (cryo-EM) to visualize biomolecules at the atomic level, combining cryo-EM with a method used in...

Decibel Therapeutics develops treatments to restore and improve hearing, balance
Decibel Therapeutics is helping to break down the barriers to understanding the molecular pathways and cell physiology inside the inner ear by integrating...