Scientists discover novel mechanism by which neurons, glia collaborate

By The Science Advisory Board staff writers

June 20, 2022 -- Champalimaud Foundation scientists have discovered a novel mechanism by which neurons and glia collaborate to drive neural regeneration following brain injury. Their findings may help develop drugs to promote the formation of new neurons following brain damage.

While neural stem cells partially activate in response to tissue damage, full activation occurs only in a small fraction of stem cells. However, results of the study published in the journal Developmental Cell may help stimulate regeneration for severe head trauma and strokes.

"We have revealed how neural stem cells sense injury and are recruited for tissue repair. These findings may be the first step towards developing drugs to promote the formation of new neurons following brain damage," said Champalimaud Foundation's Christa Rhiner, PhD, the study's senior author.

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