Cytovia, Cellectis partner on gene-edited NK cells

By The Science Advisory Board staff writers

February 16, 2021 -- Cytovia Therapeutics and Cellectis have entered into a strategic research and development collaboration to develop gene-edited natural killer (NK) and chimeric antigen receptor (CAR) NK cells derived from induced pluripotent stem cells.

Cellectis will develop custom transcription activator-like effector nuclease (TALEN) gene editing platforms, which Cytovia will use to edit iPSCs. Cytovia will be responsible for the differentiation and expansion of the gene-edited iPSC master cell bank into NK cells and will conduct the preclinical evaluation, clinical development, and commercialization of the mutually agreed upon selected therapeutic candidates.

Additionally, Cellectis is granting Cytovia a worldwide license to its TALEN gene editing technology, allowing Cytovia to modify NK cells addressing multiple gene targets for therapeutic use in several cancer indications. TALEN products are designed by fusing DNA nuclease to transcription activator-like effectors (TALE) domains.

Under the partnership, Cytovia will provide Cellectic with up to $760 million in development, regulatory, and sales milestone payments for the first five TALEN products. Cellectis will also receive royalty payments on the net sales of all partnered products commercialized by Cytovia. Cellectis will receive an equity stake of $15 million in Cytovia stock or an upfront cash payment of $15 million if certain conditions are not met by December 31, 2021, as well as an option to invest in future financing rounds.

Cytovia licenses CAR NK tech to NCI
Cytovia Therapeutics has signed a licensing agreement with the National Cancer Institute (NCI), part of the National Institutes of Health, to apply its...

Copyright © 2021 scienceboard.net


Conferences
Microscopy and Microanalysis Meeting
July 31 - August 4
Portland, Oregon United States
Glasgow International Health Festival
August 24-27
Glasgow, Glasgow City United Kingdom
Pharma Competitive Intelligence Conference and Exhibition
September 21-22
Newark, New Jersey United States
BioProcess International (BPI) Conference
September 27-30
Boston, Massachusetts United States
Connect
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter