Poseida, TScan partner on allogenic TCR therapies for COVID-19

By The Science Advisory Board staff writers

October 21, 2020 -- Poseida Therapeutics and TScan Therapeutics are joining forces to develop T-cell receptor (TCR) therapies for the treatment of COVID-19.

Poseida's allogeneic T-cell platform will be used with TScan's immunodominant epitopes and TCR sequences to develop and commercialize allogeneic TCR T-cell therapies.

Much of the current COVID-19 research has focused on neutralizing antibodies that block viral infection or small molecule drugs that inhibit viral replication. This partnership instead focuses on cellular therapy, particularly T-cell responses, because emerging research shows patients who fail to mount effective T-cell responses often end up with more severe and life-threatening disease. Injecting virus-specific, engineered T cells may mitigate this effect.

TScan said generating a memory T-cell response targeting specific proteins could be important for fighting the virus and for long-term immunity. Adding in Poseida's allogeneic T-cell product, which generates a very high percentage of stem cell memory T cells, has the potential to yield hundreds of doses from a single manufacturing run, the firms said.

Under the partnership, Poseida will gain access to TScan's data and intellectual property related to TCR sequences and targets and TScan will provide TCR expertise. Other details, particularly financial, were not disclosed.

Neogene Therapeutics to develop personalized cell therapies
Neogene Therapeutics is pioneering a new class of fully personalized neoantigen T-cell therapies to treat cancer supported by $110 million in series...

Copyright © 2020 scienceboard.net


Conferences
Northeast Regional Laboratory Staff and Core Directors (NERLSCD) 2021
November 3-5
Portsmouth, New Hampshire United States
CPhI Worldwide 2021
November 9-11
Milan, Lombardia Italy
Society for Immunotherapy of Cancer (SITC) Annual Meeting
November 10-14
Washington, DC, District of Columbia United States
Connect
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter