Twist Bioscience finds new SARS-CoV-2 neutralizers

By The Science Advisory Board staff writers

September 2, 2020 -- Twist Bioscience has identified immunoglobulin G (IgG) antibodies and single dose domain VHH nanobodies that have neutralizing effects against SARS-CoV-2.

The neutralizing effects identified suggest infections in humans can be blocked. Additionally, the effects were equal to or better than those found in antibody candidates derived from patients who had recovered from COVID-19, according to data collected from in vitro studies conducted by Saint Louis University and independently verified by scientists at Colorado State University.

The studies involved testing more than 200 monoclonal and VHH antibodies against live virus and pseudovirus cells. Each antibody was chosen for its high and unbiased binding affinity to either the receptor binding domain of the S1 protein of SARS-CoV-2 or the extracellular domain of angiotensin I converting enzyme 2 (ACE2) in human cells.

Currently, the antibodies moving through clinical development for the treatment of COVID-19 are IgG antibodies, many of which show promise. The VHH antibodies included in these assays may represent a different path to treating the disease. Since the nanobodies are much smaller than IgG antibodies, they may be able to access epitopes on the virus that IgGs can't.

Twist Bioscience, Seismic Bio partner to discover bispecific antibodies
Twist Bioscience and Seismic Bio have formed a partnership to discover and optimize antibodies to high-value immuno-oncology targets.
Takeda, Twist partner on biologics discovery
Twist Bioscience and Takeda Pharmaceutical have formed a partnership for access to Twist's proprietary phage display libraries for the discovery of antibodies...
Twist, Serimmune identify SARS-CoV-2 antibody therapies
Twist Bioscience has joined forces with Serimmune to identify and evaluate SARS-CoV-2 therapeutic antibody candidates.
Twist's SARS-CoV-2 quality controls added to FDA materials
Twist Bioscience's synthetic SARS-CoV-2 RNA quality controls for the development, verification, and validation of diagnostic tests for SARS-CoV-2 are...
Twist Bioscience partners with Miroculus on clinical products
Synthetic biology company Twist Bioscience announced on February 25 that it has initiated a collaboration with digital microfluidics developer Miroculus...

Copyright © 2020 scienceboard.net


Register below for our weekly Letter from the Editor to receive the latest Science news and insights.
Email
Connect
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter