Valo to develop pan-coronavirus vaccine

By The Science Advisory Board staff writers

April 27, 2020 -- Valo Therapeutics announced that it is working on the development of a potential COVID-19 vaccine with applications across future pandemics.

The company will use its peptide-coated conditionally replicating adenovirus (PeptiCRAd) technology to coat an adenovirus vector, engineered to express coronavirus spike proteins with human leukocyte antigen-matched peptides that boost CD8+ T-cell immune responses. Both components had to be tested individually in the past, and the company believes that it will be much quicker to manufacture clinical-grade peptides for coating an adenoviral vector rather than reengineering a new virus. Moreover, this approach allows flexibility and rapid clinical testing if a new coronavirus strain emerges.

A T-cell vaccine could be useful, according to the company, because coronaviruses produce neutralizing antibodies that require cell-mediated clearance. The company hopes that the combination of adenoviral vectors will produce strong T-cell mediated immune responses and that the SARS-CoV-2 spike proteins will produce antibody-mediated immune responses. The additional coating with selected peptides will serve to further boost the cell-mediated response and broaden the immune targets.

AGC Biologics, AdaptVac partner on COVID-19 vaccine
AGC Biologics, a contract development and manufacturing organization, and AdaptVac have teamed up to develop a COVID-19 vaccine.
Nonprofit seeks COVID-19 vaccines for most vulnerable
The nonprofit consortium Human Vaccines Project has launched an initiative to ensure COVID-19 vaccines are developed for vulnerable populations.
J&J announces manufacturing collaboration for COVID-19 vaccine
Johnson & Johnson, a Janssen Pharmaceuticals company, announced on April 24 a collaboration with Emergent BioSolutions to support the manufacturing...

Copyright © 2020 scienceboard.net


Register below for our weekly Letter from the Editor to receive the latest Science news and insights.
Email
Conferences
ESMO Virtual Congress 2020
September 14-29
Online
BioProcess International West
September 21-25
Online
BioProcess International
September 21-25
Online
ASGCT 2020 Policy Summit
September 23-25
Online
Connect
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter