Carisma, NYU Langone to develop Vpx lentiviral vector

By The Science Advisory Board staff writers

August 25, 2020 -- Carisma Therapeutics has entered into a scientific research and licensing agreement with NYU Langone Health to attain exclusive rights to develop and commercialize a Vpx lentiviral vector globally for all indications.

The Vpx lentiviral vector is effective at transducing human monocytes, macrophages, and dendritic cells. The vector will broaden the utility of Carisma's engineered monocyte and macrophage platforms by enabling integration of transgenes for long-term, durable expression.

Carisma is partnering on the project with Nathaniel Landau, PhD, a professor in the department of microbiology at the NYU Grossman School of Medicine and inventor of the Vpx lentiviral vector.

The partnership builds on Carisma's recent U.S. Food and Drug Administration clearance of an investigational new drug (IND) application for its lead product candidate, CT-0508, an anti-human epidermal growth factor receptor 2 (HER2) targeted chimeric antigen receptor macrophage (CAR-M). The company plans to begin a phase I clinical trial for the candidate in solid tumors later this year.

Expression Therapeutics develops stem cell lentiviral gene therapy
Expression Therapeutics has developed a potentially curative gene therapy candidate for familial hemophagocytic lymphohistiocytosis type 3.
Carisma advances macrophage immunotherapy
Carisma Therapeutics' engineered macrophage immunotherapy has cleared an investigational new drug application through the U.S. Food and Drug Administration....
Horizon Discovery accelerates CRISPR gene editing workflows
Horizon Discovery Group has introduced a new stably expressing Cas9 cell line for knockout experiments and a dCas9-VPR cell line for gene activation experiments.
Avrobio moves forward with gene therapy candidate
Avrobio released preclinical data for AVR-RD-03, lentiviral gene therapy for Pompe disease, at the American Society of Gene and Cell Therapy annual meeting...

Copyright © 2020 scienceboard.net


Conferences
International Society for Cell and Gene Therapy Annual Meeting
May 4 - June 7
San Francisco, California United States
Interphex 2022 Conference
May 24-26
New York, New York United States
American Society for Mass Spectrometry Annual Conference
June 5-9
Minneapolis, Minnesota United States
American Society for Microbiology Microbe Meeting
June 9-13
District of Columbia United States
HPLC 2022
June 18-23
San Diego, California United States
Connect
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter