VBI touts positive preclinical COVID-19 vaccine data

By The Science Advisory Board staff writers

April 28, 2021 -- Preclinical data suggest positive results from a COVID-19 vaccine candidate based on enveloped viruslike particle (eVLP) technology from VBI Vaccines (VBI).

Candidate VBI-2902 expressed a modified,‌ ‌prefusion‌ ‌form‌ ‌of‌ ‌the‌ ‌SARS-CoV-2‌ ‌spike‌ ‌protein‌ that ‌elicited‌ ‌a‌ ‌highly‌ ‌potent‌ ‌and‌ ‌focused‌ ‌neutralizing‌ ‌antibody‌ ‌response ‌and‌ ‌conferred‌ a ‌protective‌ ‌benefit‌ ‌in‌ ‌Syrian‌ ‌golden‌ ‌hamsters‌ that had ‌COVID-19. This was ‌assessed‌ ‌in‌ ‌terms‌ ‌of‌ ‌clinical‌ ‌disease‌, such as loss‌ ‌of‌ ‌body‌ ‌weight and‌ ‌lung‌ ‌inflammation. Also, the ‌vaccine‌ ‌candidate‌ ‌showed potential to be highly effective after a single dose, according to the data.

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