Reverie Labs, Roche to advance kinase drug discovery

By The Science Advisory Board staff writers

July 8, 2020 -- Reverie Labs is partnering with Roche and Genentech to advance next-generation kinase inhibitors with the use of artificial intelligence.

Reverie will use its technology platform to perform virtual screening, hit-to-lead generation, and lead optimization of several kinase inhibitor discovery programs in collaboration with Roche and Genentech scientists. Reverie will use its scalable infrastructure to train machine-learning models for kinase potency, kinome selectivity, and metabolism and toxicity properties to generate millions of novel chemical structures to evaluate.

Under the agreement, Reverie will receive an upfront payment of an undisclosed amount and will be eligible for preclinical, clinical, and regulatory milestone payments, as well as tiered royalties on Roche's sale of drug candidates produced from the collaboration.

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