How to develop a sustainable portfolio for cell, gene therapy platforms

June 13, 2022

Which indications to develop first and when to seek partnerships are two critical decisions that emerging biotech companies must make. Those are among the issues that will be addressed at a June 14 panel on developing a sustainable portfolio for cell and gene therapy platforms at the 2022 Biotechnology Innovation Organization (BIO) International Convention.

Michael Retterath, a BIO 2022 panelist and chief business officer at Spark Therapeutics, spoke to about his company's transition from a research center to a private, venture-backed startup and a publicly traded company.

Founded in 2013, Spark is the first company to receive U.S. Food and Drug Administration approval of a gene therapy for a genetic disease, and in 2019 it was acquired by Roche for $4.8 billion.

"As one of the leaders and with Roche's support, we have the ability to have more of a portfolio view and look across disease areas, tissue types, and assets," said Retterath, whose responsibilities at Spark include portfolio and technology prioritization.

When it comes to developing a sustainable portfolio, Retterath said there is a "structured way of thinking" through the opportunities. "There are constantly setbacks and frustrations early on," he noted, but it's about "making choices that de-risk subsequent choices" and "also give insights that help you address subsequent choices."

Watch the video below to learn more.

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Last Updated 7/20/2022 2:30:47 PM