MachineBio offers path toward single-step protein synthesis and purification The next featured company in the BioTools Innovator accelerator contest is MachineBio. The company has developed a protein synthesis platform that can produce pure protein from a DNA template in a single-step process that takes four hours. We spoke with David Marash, co-founder, CEO, and head of scientific operations for MachineBio, as part of our coverage of the competition.Read More
New software finds relationships between RNA modifications, cancers A new computational tool called ModTect could identify RNA modifications using preexisting sequencing data gathered from clinical cohort studies. The tool may bring scientists closer to understanding the relationships between RNA modifications and the development of cancer and other diseases, according to a recent study in Science Advances.Read More
Vaccine for tooth decay? It's not science fiction, says NIH A vaccine for caries could be possible under a new division of the U.S. National Institutes of Health (NIH) that has been tasked with using "crazy, bold ideas" to prevent and cure disease. Health leaders introduced the proposed agency at a September 9 meeting of the National Institute of Dental and Craniofacial Research.Read More
New gene therapy platform shows potential against certain muscle diseases Scientists have engineered a new family of adeno-associated viruses (AAVs) to deliver therapeutic genes to muscle tissue at 100 to 250 times lower doses than previous AAV vectors, potentially reducing the risk of liver damage and other serious side effects, according to a new study published in Cell on September 9.Read More
Celldom has its eye on low-cost, scalable single-cell analysis Celldom, a startup based in Durham, NC, has developed a low-cost, high-throughput, single-cell analysis platform designed to investigate and classify rare cells associated with diseases like cancer. The company is one of 10 semifinalists in the BioTools Innovator accelerator contest. We spoke with co-founder and CEO Benjamin Yellen as part of our exclusive coverage of the competition.Read More
Glyphic Biotechnologies is developing a single-molecule-resolution protein sequencing platform Glyphic Biotechnologies is developing a novel protein sequencing platform that allows researchers to determine each amino acid in a protein sequence. The company is one of 10 semifinalists in the BioTools Innovator accelerator contest, and we spoke with co-founder and CEO Josh Yang as part of our exclusive coverage of the competition.Read More
How challenging risky ideas fuels the research ecosystem If you knew that an experiment would fail, would it be worthwhile to conduct if it had the potential to challenge fundamental hypotheses about science? In a recent interview with ScienceBoard.net, world-renowned Stanford University scientist and serial entrepreneur Stephen Quake, PhD, discussed the value of basic research and his contributions to the biomedical field.Read More
How EpiCypher is quantifying and scaling chromatin science EpiCypher is developing tools based on its designer nucleosome technology to enable epigenetics-focused drug development for a variety of chromatin biology applications. The company is one of 10 semifinalists in the BioTools Innovator accelerator contest. We spoke with Martis Cowles, chief business officer, as part of our exclusive coverage of the competition.Read More