Ebola vaccine protocols found safe for all ages
Two randomized, placebo-controlled trials evaluating three Ebola vaccine administration strategies in adults and children found that all regimens were safe in both age groups. The research, published last week in the New England Journal of Medicine, was conducted under the international consortium Partnership for Research on Ebola Vaccination (PREVAC). Read More
Plant offers potential for massive scale production of COVID-19 tests, vaccines
Viral antigen-based diagnostic tests as well as various vaccines have been key tools in fighting COVID-19. Read More
Common genetic cause of late-onset ataxia revealed
A Quebec-led international collaboration has discovered a previously unknown common genetic cause of late-onset cerebellar ataxia. The study, published December 14 in the New England Journal of Medicine, may potentially improve diagnosis and open new treatment avenues for thousands of people with this debilitating neurodegenerative condition worldwide. Read More
AMP assesses clinical implementation of past standards, guidelines for sequence variants in cancer
The Association for Molecular Pathology (AMP) on Tuesday announced that it has published a report to assess clinical adoption, identify classification inconsistencies, and evaluate implementation barriers for the 2017 report, “Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists.” Read More
CRISPR system targets toxic RNA to improve Huntington's in mice
Genome-editing CRISPR technology has reduced the toxic RNA that drives Huntington's disease in mice, providing preclinical proof of principle for a new way to treat the fatal neurodegenerative disorder, according to a study published on December 12 in Nature Neuroscience. Read More
Discovery of toxin linked to severe COVID-19 points to new way to treat disease
A viral toxin produced by the SARS-CoV-2 virus may damage cell barriers, inducing vascular leak and driving severe COVID-19 infections, according to researchers at the University of California, Berkeley (UC Berkeley). Read More
AI provides evidence that gene length explains age-related molecular changes
Artificial intelligence (AI) has helped Northwestern University researchers find evidence that the length of genes explains most of the molecular-level changes that occur during aging, which they contend could lead to therapeutics that slow or even reverse the process. Read More
Functional genomics reveals gateway to intracellular targets for large molecules
Complementary genome-scale, chemical-genetic approaches have revealed a cellular gateway that could allow large molecules to enter cells, providing new opportunities to develop drugs for intracellular targets, according to University of California San Francisco (UCSF) researchers. Read More
Analysis of T-cell receptors sheds light on cause of autoimmune diseases
An analysis of T-cell receptors by researchers at the Washington University School of Medicine, and colleagues at Stanford University and Oxford University, has generated evidence that microbial antigens and self-antigens could play a pathogenic role in certain autoimmune diseases. Read More
New research shows smallpox vaccine trains T cells to recognize mpox
Scientists from the La Jolla Institute for Immunology have found new evidence that the vaccinia vaccine MVA-BN (brand name JYNNEOS) can train virus-fighting T cells to recognize the monkeypox (mpox) virus. Read More
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