Genetically engineered probiotics successfully deliver immunotherapies
A new technology enables genetically engineered probiotic bacteria to be used as an efficacious, stable, and safe platform to deliver immunotherapies directly into a variety of tumors in just a single dose. The research was published online on February 12 in Science Translational Medicine. Read More
Phages containing huge amounts of DNA are found around the globe
An inventory of over 350 DNA sequences from phage genomes revealed that these genomes can be over 200,000 base pairs in length and found the largest phage genome ever described at 735,000 base pairs in length. The report published in Nature on February 12, evaluated the prevalence, diversity and ecosystem distribution of phages with large genomes. Read More
T cells work as a team to fight infection
Immune cells may be better at sensing each other than previously thought, according to a new study published in Immunity on February 11. Researchers from Germany, the Netherlands, and the U.K. revealed a mechanism T cells use to work as a team and mutually determine how to fight infections. Read More
CRISPR proteins developed for use in molecular diagnostics
New CRISPR technology is being developed as a molecular diagnostic tool with the capability of detecting unique disease biomarkers. Eventually, these at-home tests will allow patients to conduct at-home diagnostic tests quickly. Read More
Could a plant virus help create a new MRI contrast agent?
What's old is new for University of Texas at Dallas researchers who are resurrecting an organic, biodegradable compound that someday might be the foundation for a nongadolinium-based magnetic resonance imaging (MRI) contrast agent, according to a preclinical study published online on February 5 in Chemical Science. Read More
3D model of human intestines helps simulate leaky gut condition
Researchers are using 3D models of human intestines to simulate leaky gut conditions -- in which microbes and molecules seep out of the intestines, eliciting an immune response. The research, published in Life Science Alliance on February 10, will help identify biomarkers for leaky gut for improved diagnostics and treatment development. Read More
Experts map the future of bioprinting
Bioprinting has rapidly advanced in both techniques and clinical applications, but key challenges still remain for the burgeoning field. A multinational team of researchers offered their recommendations for how to address these hurdles in an in-depth road map article published February 7 in Biofabrication. Read More
Genomics sheds light on the life history of cancers
As part of a special collection of papers on pan-cancer analysis of whole genomes published online by Nature on February 6, an international group of scientists analyzed over 2,500 unique cancer genomes to shed light on the life history of cancer mutations and how cancer tumors evolve -- even before they are diagnosed. Read More
New fluorescence technique builds more vivid views
A novel imaging technique improves processing time of hyperspectral fluorescence imaging and allows scientists to peer more deeply and clearly into living organisms. Researchers from the University of Southern California Michelson Center for Convergent Bioscience have been developing the technology for years and have published their findings in Nature Communications on February 5. Read More
Hydrogels enable on-demand production of pharmaceuticals
A first-in-class system that effectively embeds engineered microbes into the solid support of a 3D-printed hydrogel is described in a report published in Nature Communications on February 4. The hydrogel system organizes both individual microbes and groups of microbes for on-demand production of pharmaceuticals. Read More
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