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Bioimaging & Microscopy
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Scientists see through human organs for the 1st time
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For the first time, scientists have made human organs transparent with the use of a new imaging technique called SHANEL, which stands for small-micelle-mediated human organ efficient clearing and labeling. The details were published in Cell on February 13.
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Bioprocessing Sponsored by MilliporeSigma
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Microscale flow chemistry uses 'switchable solvents' to improve extraction
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New green technology enables accelerated screening and retrieval of "switchable" solvents for chemical and pharmaceutical applications. Utilizing microfluidic strategies, researchers developed an in situ approach to study gas-liquid processes in a time- and material-efficient manner. The work was published online in ACS Sustainable Chemistry and Engineering on February 6.
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MilliporeSigma to make Elypta liquid biopsy kits
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MilliporeSigma has signed an agreement with Swedish molecular diagnostics company Elypta to be the contract manufacturer for Elypta's clinical diagnostic liquid biopsy kits.
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Audentes plans gene therapy facility in NC
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Audentes Therapeutics has announced that it plans to invest $109 million to build a new 135,00-sq-ft gene therapy manufacturing facility in Sanford, NC, that is expected to be operational by 2021.
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Thermo Fisher, NanoPin partner on infectious disease tech
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Thermo Fisher Scientific will partner with infectious diseases diagnostic company NanoPin Technologies to develop workflows for liquid chromatography-mass spectrometry.
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Bioprocessing Summit Europe to be held March 24-26
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The Bioprocessing Summit Europe will return to Barcelona, Spain, this year to address the growing global market for gene therapy and biopharmaceutical manufacturing. The summit will take place from March 24 to 26.
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Cancer & Disease Research
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Communication of cancer cells analyzed with organoids and novel cytometry
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A new technique using organoids, self-organizing 3D tissue models, can decipher how individual cancer cells communicate with each other and the unique signals they create. This research, published in Nature Methods on February 17, could be used to help develop personalized cancer treatments in the future.
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Drug Discovery & Development
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Breakthrough in coronavirus research provides map for vaccines
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Critical research reveals the 3D atomic-scale map of the spike protein of the 2019 novel coronavirus (2019-nCoV), which is responsible for infecting humans. This breakthrough will aid in the development of vaccines and antiviral drugs to combat the spread of the virus. The research was published in Science on February 19.
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Immunology
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Genetically engineered probiotics successfully deliver immunotherapies
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A new technology enables genetically engineered probiotic bacteria to be used as an efficacious, stable, and safe platform to deliver immunotherapies directly into a variety of tumors in just a single dose. The research was published online on February 12 in Science Translational Medicine.
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Proteomics
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Atomic structures revealed by cryo-EM may lead to new antiviral drugs
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Using cryo-electron microscopy (cryo-EM), researchers found unique structures of paramyxoviruses that can lead to a better understanding of viral replication, which in turn can be leveraged to develop improved antiviral drugs. The details were published in the Proceedings of the National Academy of Sciences on February 17.
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Dear Science Advisory Board Member,
As coronavirus continues to be a threat to public safety, researchers are taking a deep dive into the structure of the 2019 novel coronavirus' spike protein to provide an atomic map for vaccine development. Atomic structures revealed by cryo-electron microscopy of paramyxoviruses also are providing a template for the development of other antiviral drugs.
Meanwhile, researchers have developed a new tissue-clearing technique called SHANEL, which allows them to see through human organs for the first time. This technique will be crucial for bioprinting artificial tissues in the future.
Other researchers are using organoids to explore how cancer cells communicate via post-translational modifications and how to identify key signaling molecules indicating pathology.
Have you visited our Bioprocessing Community recently? If not, I recommend you check out our new article on "switchable" solvents, which have the potential to transform downstream manufacturing processes.
Samantha Black, PhD
The Science Advisory Board Editor
editor@scienceboard.net
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