February 8, 2022 -- Bruker Corporation has launched its trapped ion mobility spectronomy time-of-flight (timsTOF) matrix-assisted laser desorption/ionization (MALDI) PharmaPulse (MPP) system, a new solution for unbiased, deep, high-throughput screening (HTS) and ultra HTS (uHTS) based on label-free mass spectrometry, at the SLAS 2022 International Conference and Exhibition.
The new timsTOF MPP is the flagship of Bruker's MALDI PharmaPulse product family. The timsTOF MPP features the speed and robustness of MALDI, Bruker said. And, for the first time in HTS, the MPP takes advantage of Bruker's innovative tims technology. Tims enables rapid gas-phase separation of isobars, and even isomers, by exploiting the molecular collisional cross section. This, in combination with routine 50,000 mass resolution at full speed with quadropole time-of-flight mass spectrometry detection, enables revolutionary levels of assay specificity at HTS speed.
The timsTOF MPP features a dual MALDI/electrospray ionization ion source with a 10-kHz Smartbeam 3D laser to enable uHTS-compatible speed and throughput. The new MALDI PharmaPulse 2023 software supports a broad range of HTS applications for drug discovery, Bruker added.
Bruker's scientific instruments and analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular, and microscopic levels.
The Bruker timsTOF MALDI PharmaPulse System.
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