April 1, 2021 -- Unchained Labs has rolled out new gene therapy and vaccine applications on its Big Tuna automated buffer exchange platform for biologics. The system can now buffer adeno-associated viruses (AAVs) and lipid nanoparticles (LNPs).
Buffer exchange is a common step in biologics preparation workflows. Big Tuna automates buffer exchange to formulate, concentrate, and clean up proteins or gene therapy vectors like AAVs, LNPs, and viruslike particles (VLPs).
AAVs are produced at low concentrations and need to be concentrated up for characterization processes, and LNPs are made in the presence of ethanol and need to be cleared quickly for stabilization prior to dosing.
Using Big Tuna's new high molecular weight cutoff plates, concentration application, and tunable pressure settings, AAVs and LNPs can concentrated at precise specifications required by the user.
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