Integral Molecular aids with safety testing of COVID-19 antibodies

By The Science Advisory Board staff writers

June 12, 2020 -- Integral Molecular is applying its membrane proteome array (MPA) technology for antibody specificity profiling to accelerate development of SARS-CoV-2 therapeutic antibodies.

In collaboration with Abound Bio, the MPA technology has been used to identify a monoclonal antibody that targets and neutralizes SARS-CoV-2. The antibody did not display any off-target binding on the MPA and has been selected for further development.

Nearly 25% of preclinical antibodies have off-target binding to unintended protein targets, which can lead to adverse effects in patients. The company's MPA provides specificity results in less than a month, which is faster than other traditional preclinical safety experiments, according to the company.

The MPA is a collection of 6,000 membrane proteins expressed in live cells, representing nearly the entire human membrane proteome. Integral has also launched an antibody neutralization test using pseudotyped SARS-CoV-2 reporter viruses.


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