NanoString uses tech to assess ties between tumor cells and immune cells

By The Science Advisory Board staff writers

August 31, 2021 -- NanoString Technologies is directing attention to research published online August 26 in Cell involving its GeoMx Digital Spatial Profiler (DSP) technology.

In a study involving 28 mismatch repair-proficient tumors and 34 mismatch repair-deficient colorectal cancer samples, researchers from the Broad Institute of MIT and Harvard used single-cell transcriptomics, in situ hybridization, and GeoMx DSP to assess the mechanisms governing interactions between colorectal tumor cells and tumor-infiltrating immune cells.

The researchers quantified cellular programs defined by single-cell RNA sequencing and mapped their interactions using the GeoMx Cancer Transcriptome Atlas assay across 135 regions of interest in a subset of tumors with a high number of potentially tumor-reactive T cells. This revealed the spatial transcriptional regulation that organizes immune-malignant cell networks, according to the company.

Copyright © 2021
To access all The ScienceBoard content create a free account now:

Email Address:  

First Name:

Last Name:

Learn about ScienceBoard

Get the latest life sciences research and industry news, delivered straight to your inbox, for free.

Why subscribe?

ScienceBoard is uniquely focused on the business of research, addressing the biggest problems that the biomedical industry face. You’ll get breaking news, events coverage, and deep dives into the science that drives innovation, delivered to your inbox daily.

Letter from the Editor Please send me twice-weekly roundups of all the latest life research and industry news.
SAB Announcements Please send me the latest announcements from The Science Advisory Board and their partners.
Spotlight Receive notifications about new content, services, or educational resources designed to help you sharpen your skills and grow professionally.
I have read and agree to the privacy policy and terms of service and wish to opt-in for

Already have an account? Sign in here