The compound will be investigated for nonalcoholic steatohepatitis. RNAi destroys messenger RNA made from genes, which can prevent the creation of disease-causing proteins, Dicerna said. The company's GalXC technology consists of an N-acetyl-D-galactosamine (GalNAc) structure of double-stranded RNA molecules that bind to liver cell receptors.
Dicerna will receive a preclinical milestone payment from Boehringer Ingelheim for the compound, called DCR-LIV2, which it expects to receive in the second quarter of this year. Dicerna is eligible to receive up to $170 million in additional milestone payments, as well as royalties on potential global net sales.
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