Lyell completes $65M cell therapy manufacturing facility

By The Science Advisory Board staff writers

Lyell Immunopharma has completed its $65 million Lyfe Manufacturing Center in Bothell, WA. The facility will be used to produce cell products for upcoming clinical trials.

Lyell is combining its proprietary ex vivo genetic and epigenetic reprogramming technologies to develop T-cell receptors, tumor-infiltrating lymphocytes, and chimeric antigen receptor-based cell therapies.

The 70,000-sq-ft production facilities house advanced capabilities for cell therapy manufacturing. In addition to cell processing equipment and manufacturing processes necessary to expand and reengineer patient immune cells, the center will integrate advanced data and analytics approaches that enable a completely digital manufacturing process. This includes real-time data feedback and batch monitoring, as well as analytical capabilities that enable artificial intelligence and machine-learning applications to enable faster process improvements.

Lyell's Lyfe center is the first cell therapy manufacturing facility to support digital manufacturing capabilities from Amazon Web Services, including cloud computing, Internet of Things (IoT), and advanced analytics.

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