NIIMBL spends $4.6M to fund biopharmaceutical projects

By The Science Advisory Board staff writers

The National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) is spending $4.6 million to fund 10 new biopharmaceutical manufacturing projects.

The projects were selected from the institute's Project Call 4.1. The projects aim to drive innovation and advancement in the areas of cell and gene therapy manufacturing and vaccine stabilization.

The following projects were selected:

  • A fully continuous downstream process for high-titer products, which is being led by Rensselaer Polytechnic Institute
  • A multifunctional microfluidic chip for rapid vector genome and empty capsid, which is being led by North Carolina State University
  • A system for rapid testing bioburden or sterility with automated imaging, which is being led by Mango
  • Development of a fluorescence-based continuous anion-exchange high-performance liquid chromatography (AEX-HPLC) method for quantification of full, partial, and empty capsids in adeno-associated viral vector products, which is being led by the University of Massachusetts Lowell
  • Novel wicking bioreactor for T-cell expansion, which is being led by Sepragen
  • Bioprocess online training using digital twin, which is being led by Keck Graduate Institute
  • Modularized portable alliance testing online training platform to accelerate workforce innovation in biopharmaceuticals manufacturing, which is being led by Northeastern University
  • Biomanufacturing consortium for analytics and data engineering expansion, which is being led by Santa Clara University
  • Tunable radio frequency/microwave drying of biologics, which is being led by Purdue University
  • A commercial-scale, aseptic spray freeze dryer, which is being led by IMA Life North America

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