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Senescent neuron discovery in brains opens path for Alzheimer's drug development
Scientists at the Salk Institute for Biological Studies have found that neurons from people with Alzheimer's disease show deterioration and undergo a late-life stress process called cellular senescence, while senescent cells could be a way to slow neuroinflammation and neurodegeneration.
Single-cell fetal brain profiling uncovers potential ways to treat pediatric tumors
A multinational team of scientists has used single-cell profiling of freshly isolated human fetal tissue to reveal a reference map of the cell states of the most common malignant childhood brain cancer.
Signal detection enables clear imaging of human cells
Beckman Institute researchers have developed an innovative method to clearly visualize the structure and chemical composition of a human cell.
New computational method maps architecture of human tissues in unprecedented detail
Weill Cornell Medicine researchers have developed a new computational method to map the architecture of human tissues in unprecedented detail, with the potential to accelerate studies on organ-scale cellular interactions and enable powerful new diagnostic strategies for an array of diseases.
Programmable RNA-sensing technology enables manipulation of specific cell type
Researchers have developed a programmable RNA-sensing technology that triggers the production of a payload protein when it encounters specific cell types, with potential applications in diagnostics and therapeutics.
Deep-learning tool Omnipose identifies bacteria in microscope images
A deep-learning software called Omnipose is helping University of Washington researchers identify varied and miniscule bacteria in microscopy images.
Spotlighting cells in tissues allows RNA to tell their story
Harvard University researchers use “Light-Seq” method for full-transcriptome sequencing of hard-to-access cells, potentially broadening the depth and scope of investigations possible in intact tissue samples.
Researchers identify transcription factors that restore hearing in zebrafish
Certain transcription factors were able to restore hearing in zebrafish through cell regeneration and could inform treatments for hearing loss in humans, according to National Institutes of Health researchers.
Single-cell sequencing reveals spatial map of immune cells in early-stage lung cancer
Using single-cell sequencing, researchers at the University of Texas MD Anderson Cancer Center have revealed a spatial map of tumor-infiltrating B cells and plasma cells that are prevalent in early-stage lung cancers, providing a basis for finding new immunotherapy targets.
Scientists create mouse embryo only from embryonic stem cells
An international team of researchers has developed a mouse embryonic stem cell-based (ESC) in vitro model. They used only ESCs (a first), which were coaxed into becoming extraembryonic endoderm stem cells and then trophoblast stem cells.
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