Synthetic Biology

New CRISPR Cas13 system offers powerful antiviral protection
A first-of-its-kind study conducted by researchers at the Broad Institute of MIT and Harvard demonstrates that Cas13, a class 2 CRISPR system, can be used as an antiviral in cultured human cells. The research, published in Molecular Cell on October 10, suggests that the RNA-cutting enzyme can be programmed to detect and destroy RNA-based viruses.  Discuss
Driven by nanotech and other micro technologies electron microscopy market continues to grow
According to a new report from Strategic Directions International (SDI), the total market for electron microscopy instrumentation was in excess of $2.5 billion in 2018 and is expected to reach nearly $3.4 billion by 2023.  Discuss
New synthetic vaccine fights infectious disease with assistance from the data cloud
A new synthetic vaccine developed by researchers at the University of Bristol and the French National Centre for Scientific Research can be stored at warmer temperatures due to an engineered scaffold design. The details of the Chikungunya vaccine candidate are published in Science Advances on September 25.  Discuss
New targeted therapy for lung cancer using precious metals as Trojan exosomes
Researchers at the University of Edinburgh and the Universidad de Zaragoza in Spain present a novel therapeutic approach to treating cancer on September 9. The research using exosome-directed catalyst prodrug therapies was published in Nature Catalysis.  Discuss
Fluorescent molecular probe used to detect temperature inside individual cells
Modified biocompatible molecular rotor, termed boron dipyrromethene (BODIPY), has been shown to detect temperatures inside single cells. Researchers at Rice University led by chemist Angel Martí published the technique in the Journal of Physical Chemistry B.  Discuss
Building proteins from scratch – how AI is helping advance synthetic biology
A new de novo designed protein – degronLOCKR, is the first completely artificial protein switch that operates within cells. LOCKR (short for Latching, Orthogonal Cage/Key pRotein) design and initial practical applications were published in Nature on July 24, 2019. Research was conducted by research teams at UW Medicine Institute for Protein Design and the University of California San Francisco.  Discuss
Genome mining has potential uses in synthetic biology and drug discovery
Researchers discovered a cluster of genes in Pseudomonas syringae which infects plants. The results of this research were published in Science on July 19th. However, this natural product produced belongs to a special class of ribosomally synthesized and posttranslationally modified peptides.  Discuss
The European Commission pursues open science and why it’s important
Scientists believe that there is a reproducibility crisis in the scientific community where many scientists fail to reproduce experiments, according to a new report by Science | Business in July 2019. Open science is a high priority for the European Commission, with around 70% of all data generated by EU-funded programs being accessible to the public.  Discuss
Landmark study explores public understanding of science and trust in scientific and medical professionals
Understanding global perceptions and knowledge of science is of growing interest to the scientific community. Organizations such as 3M, with their State of Science Index Survey and the Wellcome Global Monitor (WGM), from the Wellcome Foundation and Gallup World Poll, explore attitudes towards science and medicine, and also confidence in scientists themselves.  Discuss
Leaders in science and engineering publications over the last decade: China and the US
Capturing the attention of policy makers and companies serving the academic research market the countries with the largest number of science and engineering (S&E) articles has significantly evolved between 2007 and 2017. China leads the list in 2017 followed by the US, a reverse from 2007, according to a May report from the NSF’s National Center for Science and Engineering Statistics.  Discuss
Conferences
Virology, Emerging Diseases & Vaccines
October 21-22
Amsterdam Netherlands
10th CNS Summit
October 31 - November 3
Boca Raton, Florida United States
11th Annual PEGS Europe
November 18-22
Lisbon Portugal
Antibody Engineering & Therapeutics
December 9-13
San Diego, California United States
Society for Laboratory Automation and Screening (SLAS) 2020
January 25-29, 2020
San Diego, California United States
General Discussion
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