Proteomics Sponsored by Bio-Rad
BioTools Innovator seeks to boost startups developing life science tools
BioTools Innovator is calling for applications to its inaugural competition to advance innovation by accelerating the growth of startups developing life science tools. Kathryn Zavala, PhD, managing director, recently discussed the program with ScienceBoard.net. Read More
Improved RNA sequencing method reveals new insights into small RNAs
Researchers have developed a new RNA sequencing method that can help discover many types of previously undetectable small RNAs. Details of the method, called panoramic RNA display by overcoming RNA modification aborted sequencing (PANDORA-seq), were published in Nature Cell Biology on April 5. Read More
X-ray crystallography identifies drugs to be repurposed for COVID-19
A new large-scale study indicates x-ray crystallography can be used to find drugs that could be repurposed to target the SARS-CoV-2 main protease. In addition to identifying 37 potential drug candidates, the study, published in Science on April 2, revealed a new binding site on the SARS-CoV-2 main protease to which drugs can bind. Read More
Cancer anti-inflammatory drug has potential to treat severe COVID-19
A new study provides evidence that an inexpensive clinical-grade inhibitor that's already approved to treat cancer, called topotecan, can be used to treat severe COVID-19, even in the late stages of the disease. The findings were published in Cell on March 30. Read More
Prime editing creates desired gene mutations without collateral damage
A new gene editing tool called prime editing was demonstrated to efficiently create cell-specific knockout mice compared to traditional gene editing techniques. While both platforms successfully created mutations, prime editing did so without measurable on-target indels or off-targeting events, according to a study published in Genome Biology on March 16. Read More
Machine-learning system ranks most effective cancer drugs
Scientists successfully trained an ensemble of machine-learning (ML) algorithms to rank clinically relevant cancer drugs based on the drugs' predicted efficacy in reducing cancer cell growth. The study, reported in Nature Communications on March 25, suggests that ML may soon be widely used to predict the most appropriate treatment for individual patients with cancer. Read More
Scientists connect gene to cancer metastasis for the first time
Researchers have identified new functionality of a previously underappreciated gene, leucine-rich repeat neuronal 4 C-terminal like (LRRN4CL), which is overexpressed in melanoma cells. They believe LRRN4CL plays an important role in cancer metastasis to the lungs and describe their findings in Communications Biology on March 23. Read More
Hydrogen maps of SARS-CoV-2 main protease point to effective repurposed drugs
Scientists have used atomic maps of hydrogen atoms to determine that the SARS-CoV-2 main protease acts in unexpected ways when it comes into contact with a drug inhibitor. The research, published in the Journal of Medicinal Chemistry on March 23, provides key insights for efforts to repurpose existing drugs to develop candidates for treating COVID-19. Read More
Scientists develop ultraspecific CAR T cells that kill only cancer cells
Scientists have devised a two-step engineering circuit that precisely targets solid tumors with chimeric antigen receptor (CAR) T cells. The engineering feat could be the next step in treating solid tumors using therapeutic T cells, a treatment that has remained out of reach for many cancer patients. The new method was detailed in a Science article on March 12. Read More
Gene therapy based on transcription factors could be effective against Alzheimer's
A type of gene therapy using transcription factors to target DNA has been shown to dramatically reduce levels of the harmful protein tau in preclinical mouse models of Alzheimer's disease. The findings, published in Science Advances on March 19, suggest that the therapy could easily translate to the clinic and be effective in humans. Read More
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